TY - JOUR
T1 - Association of Use of Statins with Progression of Diabetic Retinopathy at a Tertiary Care Hospital in Southern India
AU - Priyadarshini, Prachi
AU - Chogtu, Bharti
AU - Bhandary, Sulatha V.
AU - Kabirdev,
AU - Magazine, Rahul
N1 - Publisher Copyright:
© 2022 Iranian Society of Ophthalmology. All rights reserved.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Purpose: To study the role of statin therapy on diabetic retinopathy (DR) progression. Methods: This retrospective study was carried out at a tertiary care hospital in southern India. Data were collected from the medical records of patients admitted from January 2013 to December 2018. Out of 1673 patients of DR enrolled in the study, 171 met the inclusion criteria. Patients' demographic data, drug history, clinical characteristics, and laboratory investigations were recorded as per the pro forma. The patients were divided into statin users and nonusers. The results were analyzed to compare the DR progression between the two groups. Results: DR progressed in 67% of nonstatin users and 37% of statin users (P < 0.001). The use of statins decreased the risk of DR progression (P < 0.001). Center-involving macular edema was seen in 8 of 79 statin users (10%) and 16 of 92 statin nonusers (16%) based on optical coherence tomography findings during the follow-up period (P = 0.17). Conclusion: In patients with type 2 diabetes, lipid-lowering therapy with statins has the potential to retard DR progression.
AB - Purpose: To study the role of statin therapy on diabetic retinopathy (DR) progression. Methods: This retrospective study was carried out at a tertiary care hospital in southern India. Data were collected from the medical records of patients admitted from January 2013 to December 2018. Out of 1673 patients of DR enrolled in the study, 171 met the inclusion criteria. Patients' demographic data, drug history, clinical characteristics, and laboratory investigations were recorded as per the pro forma. The patients were divided into statin users and nonusers. The results were analyzed to compare the DR progression between the two groups. Results: DR progressed in 67% of nonstatin users and 37% of statin users (P < 0.001). The use of statins decreased the risk of DR progression (P < 0.001). Center-involving macular edema was seen in 8 of 79 statin users (10%) and 16 of 92 statin nonusers (16%) based on optical coherence tomography findings during the follow-up period (P = 0.17). Conclusion: In patients with type 2 diabetes, lipid-lowering therapy with statins has the potential to retard DR progression.
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U2 - 10.4103/joco.joco_70_21
DO - 10.4103/joco.joco_70_21
M3 - Article
AN - SCOPUS:85135722062
SN - 1735-4153
VL - 34
SP - 234
EP - 240
JO - Journal of Current Ophthalmology
JF - Journal of Current Ophthalmology
IS - 2
ER -
