Asymmetric oxidation of sulfides catalyzed by (R)-6,6'-dibromo-BINOL derived titanium complex

Narotham V. Maddireddy, Himanshu M. Godbole, Girij P. Singh, Suvarna G. Kini, Gautham G. Shenoy

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient asymmetric oxidation of sulfides was achieved using (R)-6,6'-dibromo-BINOL as chiral ligand in combination with Ti(OiPr)4 using 70% aqueous tertiary butyl hydroperoxide as oxidant. The resulting sulfoxides had high enantiopurities and good yields. A range of aryl alkyl and aryl benzyl sulfides were oxidized to the corresponding sulfoxides with 78–95% ee in 72–80% yields.

Original languageEnglish
JournalSynthetic Communications
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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