Atorvastatin-induced hepatotoxicity, increased by clopidogrel stress on CYP450 Enzyme

Understanding the mechanism through a case

Sahithi Thotakura, Ajit Singh, Kanav Khera, Sheetal Chauhan, Tom Devasia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.

Original languageEnglish
Pages (from-to)168-170
Number of pages3
JournalJournal of Applied Pharmaceutical Science
Volume8
Issue number4
DOIs
Publication statusPublished - 01-04-2018

Fingerprint

clopidogrel
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hepatitis
Enzymes
Liver
Primary Prevention
Secondary Prevention
Pharmaceutical Preparations
Wounds and Injuries
Atorvastatin Calcium

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

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abstract = "Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.",
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Atorvastatin-induced hepatotoxicity, increased by clopidogrel stress on CYP450 Enzyme : Understanding the mechanism through a case. / Thotakura, Sahithi; Singh, Ajit; Khera, Kanav; Chauhan, Sheetal; Devasia, Tom.

In: Journal of Applied Pharmaceutical Science, Vol. 8, No. 4, 01.04.2018, p. 168-170.

Research output: Contribution to journalArticle

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