Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents

Nitesh Kumar, Daniel Dhayabaran, Madhavan Nampoothiri, Krishnadas Nandakumar, A. Puratchikody, Natasha Lalani, Karima Dawood, Aanesha Ghosh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p. ), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i. p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalKorean Journal of Physiology and Pharmacology
Volume18
Issue number5
DOIs
Publication statusPublished - 01-10-2014

Fingerprint

Cedrus
Second-Generation Antidepressive Agents
Hindlimb Suspension
Rodentia
Serotonin
Pinaceae
Imipramine
Central Nervous System Diseases
Anti-Anxiety Agents
Brain
Anticonvulsants
Antidepressive Agents
Epinephrine
Norepinephrine
Therapeutics
furan

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Physiology

Cite this

@article{f8304224c6864ab8b090cfbe4c09e622,
title = "Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents",
abstract = "Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p. ), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i. p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.",
author = "Nitesh Kumar and Daniel Dhayabaran and Madhavan Nampoothiri and Krishnadas Nandakumar and A. Puratchikody and Natasha Lalani and Karima Dawood and Aanesha Ghosh",
year = "2014",
month = "10",
day = "1",
doi = "10.4196/kjpp.2014.18.5.365",
language = "English",
volume = "18",
pages = "365--369",
journal = "Korean Journal of Physiology and Pharmacology",
issn = "1226-4512",
publisher = "Korean Physiological Soc. and Korean Soc. of Pharmacology",
number = "5",

}

Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents. / Kumar, Nitesh; Dhayabaran, Daniel; Nampoothiri, Madhavan; Nandakumar, Krishnadas; Puratchikody, A.; Lalani, Natasha; Dawood, Karima; Ghosh, Aanesha.

In: Korean Journal of Physiology and Pharmacology, Vol. 18, No. 5, 01.10.2014, p. 365-369.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents

AU - Kumar, Nitesh

AU - Dhayabaran, Daniel

AU - Nampoothiri, Madhavan

AU - Nandakumar, Krishnadas

AU - Puratchikody, A.

AU - Lalani, Natasha

AU - Dawood, Karima

AU - Ghosh, Aanesha

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p. ), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i. p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.

AB - Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p. ), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i. p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.

UR - http://www.scopus.com/inward/record.url?scp=84910109778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910109778&partnerID=8YFLogxK

U2 - 10.4196/kjpp.2014.18.5.365

DO - 10.4196/kjpp.2014.18.5.365

M3 - Article

VL - 18

SP - 365

EP - 369

JO - Korean Journal of Physiology and Pharmacology

JF - Korean Journal of Physiology and Pharmacology

SN - 1226-4512

IS - 5

ER -