Automated characterization of fatty liver disease and cirrhosis using curvelet transform and entropy features extracted from ultrasound images

U. Rajendra Acharya, U. Raghavendra, Hamido Fujita, Yuki Hagiwara, Joel EW Koh, Tan Jen Hong, Vidya K. Sudarshan, Anushya Vijayananthan, Chai Hong Yeong, Anjan Gudigar, Kwan Hoong Ng

Research output: Contribution to journalArticle

50 Citations (Scopus)


Fatty liver disease (FLD) is reversible disease and can be treated, if it is identified at an early stage. However, if diagnosed at the later stage, it can progress to an advanced liver disease such as cirrhosis which may ultimately lead to death. Therefore, it is essential to detect it at an early stage before the disease progresses to an irreversible stage. Several non-invasive computer-aided techniques are proposed to assist in the early detection of FLD and cirrhosis using ultrasound images. In this work, we are proposing an algorithm to discriminate automatically the normal, FLD and cirrhosis ultrasound images using curvelet transform (CT) method. Higher order spectra (HOS) bispectrum, HOS phase, fuzzy, Kapoor, max, Renyi, Shannon, Vajda and Yager entropies are extracted from CT coefficients. These extracted features are subjected to locality sensitive discriminant analysis (LSDA) feature reduction method. Then these LSDA coefficients ranked based on F-value are fed to different classifiers to choose the best performing classifier using minimum number of features. Our proposed technique can characterize normal, FLD and cirrhosis using probabilistic neural network (PNN) classifier with an accuracy of 97.33%, specificity of 100.00% and sensitivity of 96.00% using only six features. In addition, these chosen features are used to develop a liver disease index (LDI) to differentiate the normal, FLD and cirrhosis classes using a single number. This can significantly help the radiologists to discriminate FLD and cirrhosis in their routine liver screening.

Original languageEnglish
Pages (from-to)250-258
Number of pages9
JournalComputers in Biology and Medicine
Publication statusPublished - 01-12-2016


All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics

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