Automated diabetic macular edema (DME) grading system using DWT, DCT Features and maculopathy index

U. Rajendra Acharya, Muthu Rama Krishnan Mookiah, Joel E.W. Koh, Jen Hong Tan, Sulatha V. Bhandary, A. Krishna Rao, Yuki Hagiwara, Chua Kuang Chua, Augustinus Laude

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The cause of diabetic macular edema (DME) is due to prolonged and uncontrolled diabetes mellitus (DM) which affects the vision of diabetic subjects. DME is graded based on the exudate location from the macula. It is clinically diagnosed using fundus images which is tedious and time-consuming. Regular eye screening and subsequent treatment may prevent the vision loss. Hence, in this work, a hybrid system based on Radon transform (RT), discrete wavelet transform (DWT) and discrete cosine transform (DCT) are proposed for an automated detection of DME. The fundus images are subjected to RT to obtain sinograms and DWT is applied on these sinograms to extract wavelet coefficients (approximate, horizontal, vertical and diagonal). DCT is applied on approximate coefficients to obtain 2D-DCT coefficients. Further, these coefficients are converted into 1D vector by arranging the coefficients in zig-zag manner. This 1D signal is subjected to locality sensitive discriminant analysis (LSDA). Finally, various supervised classifiers are used to classify the three classes using significant features. Our proposed technique yielded a classification accuracy of 100% and 97.01% using two and seven significant features for private and public (MESSIDOR) databases respectively. Also, a maculopathy index is formulated with two significant parameters to discriminate the three groups distinctly using a single integer. Hence, our obtained results suggest that this system can be used as an eye screening tool for diabetic subjects for DME.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalComputers in Biology and Medicine
Volume84
DOIs
Publication statusPublished - 01-05-2017

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Wavelet Analysis
Macular Edema
Discrete cosine transforms
Discrete wavelet transforms
Radon
Screening
Discriminant analysis
Medical problems
Hybrid systems
Discriminant Analysis
Classifiers
Exudates and Transudates
Diabetes Mellitus
Databases
Therapeutics

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics

Cite this

Acharya, U. Rajendra ; Mookiah, Muthu Rama Krishnan ; Koh, Joel E.W. ; Tan, Jen Hong ; Bhandary, Sulatha V. ; Rao, A. Krishna ; Hagiwara, Yuki ; Chua, Chua Kuang ; Laude, Augustinus. / Automated diabetic macular edema (DME) grading system using DWT, DCT Features and maculopathy index. In: Computers in Biology and Medicine. 2017 ; Vol. 84. pp. 59-68.
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Automated diabetic macular edema (DME) grading system using DWT, DCT Features and maculopathy index. / Acharya, U. Rajendra; Mookiah, Muthu Rama Krishnan; Koh, Joel E.W.; Tan, Jen Hong; Bhandary, Sulatha V.; Rao, A. Krishna; Hagiwara, Yuki; Chua, Chua Kuang; Laude, Augustinus.

In: Computers in Biology and Medicine, Vol. 84, 01.05.2017, p. 59-68.

Research output: Contribution to journalArticle

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