Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course

Pratik Nalinbhai Patel, Vimi Sunil Mutalik, Shweta Rehani, Raghu Radhakrishnan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC having a marked predilection for the upper aerodigestive tract. It is regarded as a high-grade tumour with increased propensity for metastasis to distant sites. The histological hallmark of BSCC is its dimorphic pattern of presentation with a characteristic basal cell component associated with squamous component. We report two cases of BSCC on the buccal mucosa and gingiva, respectively, with the former presenting as a primary lesion in a patient without a positive history of tobacco and alcohol use and the latter present as a seemingly metachronous development from carcinoma lung. The proliferative index of the two diverse yet similar entities was assessed by Ki-67 labelling index (LI) and the association of human papillomavirus (HPV) was detected with p16 monoclonal antibody. The intrinsically aggressive behaviour of BSCC and its association with HPV is highlighted.

Original languageEnglish
Article number2165
JournalBMJ Case Reports
DOIs
Publication statusPublished - 19-09-2013

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Mouth
Squamous Cell Carcinoma
Mouth Mucosa
Tobacco Use
Gingiva
Cellular Structures
Monoclonal Antibodies
Alcohols
Neoplasm Metastasis
Carcinoma
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC having a marked predilection for the upper aerodigestive tract. It is regarded as a high-grade tumour with increased propensity for metastasis to distant sites. The histological hallmark of BSCC is its dimorphic pattern of presentation with a characteristic basal cell component associated with squamous component. We report two cases of BSCC on the buccal mucosa and gingiva, respectively, with the former presenting as a primary lesion in a patient without a positive history of tobacco and alcohol use and the latter present as a seemingly metachronous development from carcinoma lung. The proliferative index of the two diverse yet similar entities was assessed by Ki-67 labelling index (LI) and the association of human papillomavirus (HPV) was detected with p16 monoclonal antibody. The intrinsically aggressive behaviour of BSCC and its association with HPV is highlighted.",
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Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course. / Patel, Pratik Nalinbhai; Mutalik, Vimi Sunil; Rehani, Shweta; Radhakrishnan, Raghu.

In: BMJ Case Reports, 19.09.2013.

Research output: Contribution to journalArticle

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