Baseline nt-probnp level as a risk predictor of contrast induced-acute kidney injury in acute coronary syndrome patients undergoing primary angioplasty

Sumit Agarwal, Hashir Kareem, Tom Devasia, Rameswer Reddy Mallu, Ganesh Paramasivam, Ajit Singh, Prasad Narayan Shetty, Suheil Dhanse

Research output: Contribution to journalArticle

Abstract

Introduction: Contrast Induced Acute Kidney Injury (CI-AKI) is a common complication of invasive cardiovascular procedures. A three-fold higher risk of developing CI-AKI has been observed in patients with Acute Coronary Syndrome (ACS) who undergo Percutaneous Coronary Intervention (PCI). Several risk score models reflecting the cumulative risk of several peri-procedural predictors, such as the Mehran CIN score and Battle Management Command and Control (BMC2) CIN score, have been established and proven. Recent data suggest that baseline NT-proBNP may help to identify ST-Elevation Mycardial Infraction (STEMI) patients at risk for CI-AKI after primary PCI. Aim: The aim of the present was to prognosticate ACS patients treated with Primary PCI for the risk of developing CI-AKI by correlating it with pre procedural NT-proBNP levels. Materials and Methods: The present study was a prospective cross-sectional observational study, involving 150 patients with ACS undergoing PCI at Kasturba Medical College, Manipal, Karnataka, India (January 2016 to December 2016). Patients with ACS (STEMI and NSTEMI) who underwent primary PCI were included in the study. Pre-existing renal derangement, acute left ventricular failure and cardiogenic shock patients were excluded from the present study. Continuous variables were described as mean±standard deviation and compared by using the t-test or Wilcoxon rank-sum test. Categorical variables are described in terms of frequency and percentage and compared using the Chi-square or Fisher exact test. The Receiver Operating Characteristic (ROC) curves, paired sample t-test and independent t-test were applied for further analysis. Results: A total of 150 patients (mean age, 63.03±9.07 years and 64.3% male) were included in the study. Among the study 22 (14.6%) patients developed CI-AKI. The value of NT-proBNP at presentation was significantly higher in patients who developed CI-AKI compared to those who did not (p<0.001). A cut off value of NT-proBNP of ≥2320 pg/mL as measured on admission has 90.9% sensitivity and 81.5% specificity in predicting CI-AKI. Conclusion: Higher Baseline NT-proBNP levels (with a cut off value of 2620.46 pg/mL) can predict the development of CI-AKI after Percutaneous Transluminal Coronary Angioplasty (PTCA) in patient with ACS.

Original languageEnglish
Pages (from-to)OC11-OC14
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number3
DOIs
Publication statusPublished - 01-03-2018

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Acute Coronary Syndrome
Angioplasty
Acute Kidney Injury
Percutaneous Coronary Intervention
Nonparametric Statistics
pro-brain natriuretic peptide (1-76)
Coronary Balloon Angioplasty
Cardiogenic Shock
ROC Curve
Observational Studies
India
Cross-Sectional Studies
Kidney
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Agarwal, Sumit ; Kareem, Hashir ; Devasia, Tom ; Mallu, Rameswer Reddy ; Paramasivam, Ganesh ; Singh, Ajit ; Shetty, Prasad Narayan ; Dhanse, Suheil. / Baseline nt-probnp level as a risk predictor of contrast induced-acute kidney injury in acute coronary syndrome patients undergoing primary angioplasty. In: Journal of Clinical and Diagnostic Research. 2018 ; Vol. 12, No. 3. pp. OC11-OC14.
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title = "Baseline nt-probnp level as a risk predictor of contrast induced-acute kidney injury in acute coronary syndrome patients undergoing primary angioplasty",
abstract = "Introduction: Contrast Induced Acute Kidney Injury (CI-AKI) is a common complication of invasive cardiovascular procedures. A three-fold higher risk of developing CI-AKI has been observed in patients with Acute Coronary Syndrome (ACS) who undergo Percutaneous Coronary Intervention (PCI). Several risk score models reflecting the cumulative risk of several peri-procedural predictors, such as the Mehran CIN score and Battle Management Command and Control (BMC2) CIN score, have been established and proven. Recent data suggest that baseline NT-proBNP may help to identify ST-Elevation Mycardial Infraction (STEMI) patients at risk for CI-AKI after primary PCI. Aim: The aim of the present was to prognosticate ACS patients treated with Primary PCI for the risk of developing CI-AKI by correlating it with pre procedural NT-proBNP levels. Materials and Methods: The present study was a prospective cross-sectional observational study, involving 150 patients with ACS undergoing PCI at Kasturba Medical College, Manipal, Karnataka, India (January 2016 to December 2016). Patients with ACS (STEMI and NSTEMI) who underwent primary PCI were included in the study. Pre-existing renal derangement, acute left ventricular failure and cardiogenic shock patients were excluded from the present study. Continuous variables were described as mean±standard deviation and compared by using the t-test or Wilcoxon rank-sum test. Categorical variables are described in terms of frequency and percentage and compared using the Chi-square or Fisher exact test. The Receiver Operating Characteristic (ROC) curves, paired sample t-test and independent t-test were applied for further analysis. Results: A total of 150 patients (mean age, 63.03±9.07 years and 64.3{\%} male) were included in the study. Among the study 22 (14.6{\%}) patients developed CI-AKI. The value of NT-proBNP at presentation was significantly higher in patients who developed CI-AKI compared to those who did not (p<0.001). A cut off value of NT-proBNP of ≥2320 pg/mL as measured on admission has 90.9{\%} sensitivity and 81.5{\%} specificity in predicting CI-AKI. Conclusion: Higher Baseline NT-proBNP levels (with a cut off value of 2620.46 pg/mL) can predict the development of CI-AKI after Percutaneous Transluminal Coronary Angioplasty (PTCA) in patient with ACS.",
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Baseline nt-probnp level as a risk predictor of contrast induced-acute kidney injury in acute coronary syndrome patients undergoing primary angioplasty. / Agarwal, Sumit; Kareem, Hashir; Devasia, Tom; Mallu, Rameswer Reddy; Paramasivam, Ganesh; Singh, Ajit; Shetty, Prasad Narayan; Dhanse, Suheil.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 3, 01.03.2018, p. OC11-OC14.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Baseline nt-probnp level as a risk predictor of contrast induced-acute kidney injury in acute coronary syndrome patients undergoing primary angioplasty

AU - Agarwal, Sumit

AU - Kareem, Hashir

AU - Devasia, Tom

AU - Mallu, Rameswer Reddy

AU - Paramasivam, Ganesh

AU - Singh, Ajit

AU - Shetty, Prasad Narayan

AU - Dhanse, Suheil

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Introduction: Contrast Induced Acute Kidney Injury (CI-AKI) is a common complication of invasive cardiovascular procedures. A three-fold higher risk of developing CI-AKI has been observed in patients with Acute Coronary Syndrome (ACS) who undergo Percutaneous Coronary Intervention (PCI). Several risk score models reflecting the cumulative risk of several peri-procedural predictors, such as the Mehran CIN score and Battle Management Command and Control (BMC2) CIN score, have been established and proven. Recent data suggest that baseline NT-proBNP may help to identify ST-Elevation Mycardial Infraction (STEMI) patients at risk for CI-AKI after primary PCI. Aim: The aim of the present was to prognosticate ACS patients treated with Primary PCI for the risk of developing CI-AKI by correlating it with pre procedural NT-proBNP levels. Materials and Methods: The present study was a prospective cross-sectional observational study, involving 150 patients with ACS undergoing PCI at Kasturba Medical College, Manipal, Karnataka, India (January 2016 to December 2016). Patients with ACS (STEMI and NSTEMI) who underwent primary PCI were included in the study. Pre-existing renal derangement, acute left ventricular failure and cardiogenic shock patients were excluded from the present study. Continuous variables were described as mean±standard deviation and compared by using the t-test or Wilcoxon rank-sum test. Categorical variables are described in terms of frequency and percentage and compared using the Chi-square or Fisher exact test. The Receiver Operating Characteristic (ROC) curves, paired sample t-test and independent t-test were applied for further analysis. Results: A total of 150 patients (mean age, 63.03±9.07 years and 64.3% male) were included in the study. Among the study 22 (14.6%) patients developed CI-AKI. The value of NT-proBNP at presentation was significantly higher in patients who developed CI-AKI compared to those who did not (p<0.001). A cut off value of NT-proBNP of ≥2320 pg/mL as measured on admission has 90.9% sensitivity and 81.5% specificity in predicting CI-AKI. Conclusion: Higher Baseline NT-proBNP levels (with a cut off value of 2620.46 pg/mL) can predict the development of CI-AKI after Percutaneous Transluminal Coronary Angioplasty (PTCA) in patient with ACS.

AB - Introduction: Contrast Induced Acute Kidney Injury (CI-AKI) is a common complication of invasive cardiovascular procedures. A three-fold higher risk of developing CI-AKI has been observed in patients with Acute Coronary Syndrome (ACS) who undergo Percutaneous Coronary Intervention (PCI). Several risk score models reflecting the cumulative risk of several peri-procedural predictors, such as the Mehran CIN score and Battle Management Command and Control (BMC2) CIN score, have been established and proven. Recent data suggest that baseline NT-proBNP may help to identify ST-Elevation Mycardial Infraction (STEMI) patients at risk for CI-AKI after primary PCI. Aim: The aim of the present was to prognosticate ACS patients treated with Primary PCI for the risk of developing CI-AKI by correlating it with pre procedural NT-proBNP levels. Materials and Methods: The present study was a prospective cross-sectional observational study, involving 150 patients with ACS undergoing PCI at Kasturba Medical College, Manipal, Karnataka, India (January 2016 to December 2016). Patients with ACS (STEMI and NSTEMI) who underwent primary PCI were included in the study. Pre-existing renal derangement, acute left ventricular failure and cardiogenic shock patients were excluded from the present study. Continuous variables were described as mean±standard deviation and compared by using the t-test or Wilcoxon rank-sum test. Categorical variables are described in terms of frequency and percentage and compared using the Chi-square or Fisher exact test. The Receiver Operating Characteristic (ROC) curves, paired sample t-test and independent t-test were applied for further analysis. Results: A total of 150 patients (mean age, 63.03±9.07 years and 64.3% male) were included in the study. Among the study 22 (14.6%) patients developed CI-AKI. The value of NT-proBNP at presentation was significantly higher in patients who developed CI-AKI compared to those who did not (p<0.001). A cut off value of NT-proBNP of ≥2320 pg/mL as measured on admission has 90.9% sensitivity and 81.5% specificity in predicting CI-AKI. Conclusion: Higher Baseline NT-proBNP levels (with a cut off value of 2620.46 pg/mL) can predict the development of CI-AKI after Percutaneous Transluminal Coronary Angioplasty (PTCA) in patient with ACS.

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