Baseline risk factors for incidence of blindness in a South Indian population: The Chennai eye disease incidence study

Lingam Vijaya, Rashima Asokan, Manish Panday, Nikhil S. Choudhari, Sathyamangalam Ve Ramesh, Lokapavani Velumuri, Sachi Devi Boddupalli, Govindan T. Sunil, Ronnie George

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Abstract

PURPOSE. To report the baseline risk factors and causes for incident blindness.

METHODS. Six years after the baseline study, 4419 subjects from the cohort underwent a detailed examination at the base hospital. Incident blindness was defined by World Health Organization criteria as visual acuity of less than 6/120 (3/60) and/or a visual field of less than 108 in the better-seeing eye at the 6-year follow-up, provided that the eye had a visual acuity of better than or equal to 6/120 (3/60) and visual field greater than 108 at baseline. For incident monocular blindness, both eyes should have visual acuity of more than 6/120 (3/60) at baseline and developed visual acuity of less than 6/120 (3/60) in one eye at 6-year follow-up.

RESULTS. For incident blindness, 21 participants (0.48%, 95% confidence interval [CI], 0.3–0.7) became blind; significant baseline risk factors were increasing age (P = 0.001), smokeless tobacco use (P < 0.001), and no history of cataract surgery (P = 0.02). Incident monocular blindness was found in 132 participants (3.8%, 95% CI, 3.7–3.8); it was significantly more (P < 0.001) in the rural population (5.4%, 95% CI, 5.4–5.5) than in the urban population (1.9%, 95% CI, 1.8–1.9). Baseline risk factors (P < 0.001) were increasing age and rural residence, and no history of cataract surgery was a protective factor (P = 0.03).

CONCLUSIONS. Increasing age was a significant risk factor for blindness and monocular blindness. No history of cataract surgery was a risk factor for blindness and a protective factor for monocular blindness.

Original languageEnglish
Pages (from-to)5545-5550
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number9
DOIs
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Vijaya, L., Asokan, R., Panday, M., Choudhari, N. S., Ramesh, S. V., Velumuri, L., Boddupalli, S. D., Sunil, G. T., & George, R. (2014). Baseline risk factors for incidence of blindness in a South Indian population: The Chennai eye disease incidence study. Investigative Ophthalmology and Visual Science, 55(9), 5545-5550. https://doi.org/10.1167/iovs.14-14614