Beneficial effect of Omega-3 polyunsaturated fatty acids on neurosensorial impairments and oxidative status in Streptozotocin induced diabetic rats

Saraswati Yadav, K. V. Mitha, Mamatha T. Shenoy, Santhosh Mayannavar, B. Ganaraja

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3 Citations (Scopus)


Objectives: The present study evaluated the beneficial effects of omega 3 PUFA present in fish oil on neurosensorial impairments, namely learning, memory and anxiety in Streptozotocin (STZ) induced diabetic rats. The brain homogenate was analysed for oxidative status following Omega 3 PUFA treatment.

Methods: Male, Wistar rats of 2-3 months old were divided into non diabetic controls, diabetic control, & fish oil treated diabetic rats (n=6). Diabetes was induced by injection of STZ (48 mg/kg, ip). Animals were treated orally for 30 days with a dose in each group of 0.5 g/kg/day of fish oil. All experiments were conducted after ethical committee clearance was obtained.

Results: Memory and exploratory behavior were improved (p<0.01) in fish oil treated rats as compared with diabetic rats. A significant (p<0.001) decrease in MDA and a significant increase (p<0.001) in total antioxidant level (TAO) were observed in fish oil treated rats.

Conclusion : Omega 3 PUFA present in fish oil could be used an adjuvant therapy for treatment and prevention of neurosensorial impairment in diabetes mellitus.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalIndian Journal of Physiology and Pharmacology
Issue number4
Publication statusPublished - 01-10-2014


All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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