Benzopyran-4-one is an ideal pharmacophore for lead optimization in antidiabetic drug discovery

Yogendra Nayak, B. S. Jayashree, M. K. Unnikrishnan

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Diabetes mellitus (DM) is a metabolic disorder associated with retinopathy, nephropathy, cardiomyopathy, peripheral neuropathy and autonomic neuropathies leading to gastrointestinal, genitourinary, cardiovascular complications and sexual dysfunction. The present available antidiabetic agents are not interferingin the modulation of these complications. Benzopyran-4-one is the basic moiety present in naturally occurring flavonoids. Number of flavonoids hasbeen found to be antidiabetic and many of themmodulate diabetes related complications by acting on newer targets. Hence, an attempt was made to review the possibilities of modulating benzopyran-4-one scaffold for lead optimization in antidiabetic drug discovery.

Original languageEnglish
Pages (from-to)1025-1033
Number of pages9
JournalResearch Journal of Pharmacy and Technology
Volume5
Issue number8
Publication statusPublished - 2012

Fingerprint

Drug Discovery
Hypoglycemic Agents
Flavonoids
Peripheral Nervous System Diseases
Diabetes Complications
Cardiomyopathies
Diabetes Mellitus
benzopyran-4-one
Lead

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

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abstract = "Diabetes mellitus (DM) is a metabolic disorder associated with retinopathy, nephropathy, cardiomyopathy, peripheral neuropathy and autonomic neuropathies leading to gastrointestinal, genitourinary, cardiovascular complications and sexual dysfunction. The present available antidiabetic agents are not interferingin the modulation of these complications. Benzopyran-4-one is the basic moiety present in naturally occurring flavonoids. Number of flavonoids hasbeen found to be antidiabetic and many of themmodulate diabetes related complications by acting on newer targets. Hence, an attempt was made to review the possibilities of modulating benzopyran-4-one scaffold for lead optimization in antidiabetic drug discovery.",
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Benzopyran-4-one is an ideal pharmacophore for lead optimization in antidiabetic drug discovery. / Nayak, Yogendra; Jayashree, B. S.; Unnikrishnan, M. K.

In: Research Journal of Pharmacy and Technology, Vol. 5, No. 8, 2012, p. 1025-1033.

Research output: Contribution to journalReview article

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