Abstract
Fused triazolothienopyrimidines were prepared from the corresponding 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile. These precursors were intern prepared by employing the Gewald's reaction. All the newly synthesized compounds were characterized by spectral and analytical data. Title compounds displayed promising antibacterial and antifungal activities. Compound 3h which exhibited good antimicrobial activity was incorporated into SLN and characterized for particle size, entrapment efficiency (EE%), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and in-vitro release studies. It showed narrow particle size distribution with high entrapment efficiency. In-vitro release study of compound loaded SLNs in phosphate buffer of pH 7.4, exhibited a biphasic pattern with an initial burst and prolonged release over 24 h.
| Original language | English |
|---|---|
| Pages (from-to) | 358-365 |
| Number of pages | 8 |
| Journal | Archiv der Pharmazie |
| Volume | 344 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 06-2011 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery
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Benzothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines : Synthesis, characterization, antimicrobial activity, and incorporation into solid lipid nanoparticles. / Panchamukhi, Shridhar I.; Mulla, Jameel Ahmed S; Shetty, Nitinkumar S.; Khazi, Mohammed Iqbal A; Khan, Ashraf Y.; Kalashetti, Mallikarjun B.; Khazi, Imitiyaz Ahmed M.
In: Archiv der Pharmazie, Vol. 344, No. 6, 06.2011, p. 358-365.Research output: Contribution to journal › Article
TY - JOUR
T1 - Benzothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines
T2 - Synthesis, characterization, antimicrobial activity, and incorporation into solid lipid nanoparticles
AU - Panchamukhi, Shridhar I.
AU - Mulla, Jameel Ahmed S
AU - Shetty, Nitinkumar S.
AU - Khazi, Mohammed Iqbal A
AU - Khan, Ashraf Y.
AU - Kalashetti, Mallikarjun B.
AU - Khazi, Imitiyaz Ahmed M
PY - 2011/6
Y1 - 2011/6
N2 - Fused triazolothienopyrimidines were prepared from the corresponding 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile. These precursors were intern prepared by employing the Gewald's reaction. All the newly synthesized compounds were characterized by spectral and analytical data. Title compounds displayed promising antibacterial and antifungal activities. Compound 3h which exhibited good antimicrobial activity was incorporated into SLN and characterized for particle size, entrapment efficiency (EE%), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and in-vitro release studies. It showed narrow particle size distribution with high entrapment efficiency. In-vitro release study of compound loaded SLNs in phosphate buffer of pH 7.4, exhibited a biphasic pattern with an initial burst and prolonged release over 24 h.
AB - Fused triazolothienopyrimidines were prepared from the corresponding 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile. These precursors were intern prepared by employing the Gewald's reaction. All the newly synthesized compounds were characterized by spectral and analytical data. Title compounds displayed promising antibacterial and antifungal activities. Compound 3h which exhibited good antimicrobial activity was incorporated into SLN and characterized for particle size, entrapment efficiency (EE%), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and in-vitro release studies. It showed narrow particle size distribution with high entrapment efficiency. In-vitro release study of compound loaded SLNs in phosphate buffer of pH 7.4, exhibited a biphasic pattern with an initial burst and prolonged release over 24 h.
UR - http://www.scopus.com/inward/record.url?scp=79958204030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958204030&partnerID=8YFLogxK
U2 - 10.1002/ardp.201000227
DO - 10.1002/ardp.201000227
M3 - Article
C2 - 21456079
AN - SCOPUS:79958204030
VL - 344
SP - 358
EP - 365
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
SN - 0365-6233
IS - 6
ER -