Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

Muthukumar Amirthalingam, Narayanan Kasinathan, Arul Amuthan, Srinivas Mutalik, M. Sreenivasa Reddy, Udupa Nayanabhirama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p < 0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume45
Issue number2
DOIs
Publication statusPublished - 17-02-2017

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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