Biodegradable dental implants of ciprofloxacin β-cyclodextrin inclusion complex in the treatment of periodontitis

R. Nagaraju, N. Udupa, J. Mathew, B. R.R. Varma

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dental implants of ciprofloxacin β-cyclodextrin inclusion complex were formulated using poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters, viz. gingival index, plaque score, attachment gain, reduction in pocket depth were evaluated at 10, 20, 30, 40 days of treatment and compared with placebo as control. A significant (P < 0.0001) improvement in the healing of peridontal pockets treated with ciprofloxacin β-cyclodextrin implant was observed in most of the clinical parameters. Estimation of gingival crevicular fluids (GCF) for the drug content revealed that drug levels above the minimum inhibitory concentration (10.2 μg/mg) for many of the periodontal pathogens were maintained throughout the period of study (40 days). This confirms the clinical efficacy of the dose and the duration of the study. It was found that biodegradable carrier was better accepted than the non-biodegradable carriers reported earlier.

Original languageEnglish
Pages (from-to)305-307
Number of pages3
JournalIndian Journal of Experimental Biology
Volume37
Issue number3
Publication statusPublished - 1999

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Absorbable Implants
Dental Implants
Periodontitis
Cyclodextrins
Ciprofloxacin
Gingival Crevicular Fluid
Periodontal Index
Microbial Sensitivity Tests
Pharmaceutical Preparations
Polymers
Placebos
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Dental implants of ciprofloxacin β-cyclodextrin inclusion complex were formulated using poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters, viz. gingival index, plaque score, attachment gain, reduction in pocket depth were evaluated at 10, 20, 30, 40 days of treatment and compared with placebo as control. A significant (P < 0.0001) improvement in the healing of peridontal pockets treated with ciprofloxacin β-cyclodextrin implant was observed in most of the clinical parameters. Estimation of gingival crevicular fluids (GCF) for the drug content revealed that drug levels above the minimum inhibitory concentration (10.2 μg/mg) for many of the periodontal pathogens were maintained throughout the period of study (40 days). This confirms the clinical efficacy of the dose and the duration of the study. It was found that biodegradable carrier was better accepted than the non-biodegradable carriers reported earlier.",
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Biodegradable dental implants of ciprofloxacin β-cyclodextrin inclusion complex in the treatment of periodontitis. / Nagaraju, R.; Udupa, N.; Mathew, J.; Varma, B. R.R.

In: Indian Journal of Experimental Biology, Vol. 37, No. 3, 1999, p. 305-307.

Research output: Contribution to journalArticle

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AU - Udupa, N.

AU - Mathew, J.

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AB - Dental implants of ciprofloxacin β-cyclodextrin inclusion complex were formulated using poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters, viz. gingival index, plaque score, attachment gain, reduction in pocket depth were evaluated at 10, 20, 30, 40 days of treatment and compared with placebo as control. A significant (P < 0.0001) improvement in the healing of peridontal pockets treated with ciprofloxacin β-cyclodextrin implant was observed in most of the clinical parameters. Estimation of gingival crevicular fluids (GCF) for the drug content revealed that drug levels above the minimum inhibitory concentration (10.2 μg/mg) for many of the periodontal pathogens were maintained throughout the period of study (40 days). This confirms the clinical efficacy of the dose and the duration of the study. It was found that biodegradable carrier was better accepted than the non-biodegradable carriers reported earlier.

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