Biodegradable microspheres of curcumin for treatment of inflammation

Virender Kumar, Shaila Angela Lewis, Srinivas Mutalik, Dinesh B. Shenoy, Venkatesh, N. Udupa

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7) was formulated as prolonged release biodegradable microspheres for treatment of inflammation. Natural biodegradable polymers, namely, bovine serum albumin and chitosan were used to encapsulate curcumin to form a depot forming drug delivery system. Microspheres were prepared by emulsion-solvent evaporation method coupled with chemical cross-linking of the natural polymers. Curcumin could be encapsulated into the biodegradable carriers upto an extent of 79.49 and 39.66% respectively with albumin and chitosan. Different drug:polymer ratios did not affect the mean particle size or particle size distribution significantly. However, the concentration of the crosslinking agent had remarkable influence on the drug release. In-vitro release studies indicated a biphasic drug release pattern, characterized by a typical burst-effect followed by a slow release which continued for several days. Evaluation of antiinflammatory activity using Freund's adjuvant induced arthritic model in Wistar rats revealed significant difference between both the formulations, albumin microspheres and chitosan microspheres as well as against control. It was evident from the present study that the curcumin biodegradable microspheres could be successfully employed as prolonged release drug delivery system for better therapeutic management of inflammation as compared to oral or subcutaneous route.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalIndian Journal of Physiology and Pharmacology
Volume46
Issue number2
Publication statusPublished - 2002

Fingerprint

Curcumin
Microspheres
Inflammation
Chitosan
Curcuma
Polymers
Drug Delivery Systems
Particle Size
Albumins
Therapeutics
Experimental Arthritis
Freund's Adjuvant
Bovine Serum Albumin
Emulsions
Wistar Rats
Anti-Inflammatory Agents
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

@article{2b0fd94d94764878a4015cfd17469fb7,
title = "Biodegradable microspheres of curcumin for treatment of inflammation",
abstract = "Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7) was formulated as prolonged release biodegradable microspheres for treatment of inflammation. Natural biodegradable polymers, namely, bovine serum albumin and chitosan were used to encapsulate curcumin to form a depot forming drug delivery system. Microspheres were prepared by emulsion-solvent evaporation method coupled with chemical cross-linking of the natural polymers. Curcumin could be encapsulated into the biodegradable carriers upto an extent of 79.49 and 39.66{\%} respectively with albumin and chitosan. Different drug:polymer ratios did not affect the mean particle size or particle size distribution significantly. However, the concentration of the crosslinking agent had remarkable influence on the drug release. In-vitro release studies indicated a biphasic drug release pattern, characterized by a typical burst-effect followed by a slow release which continued for several days. Evaluation of antiinflammatory activity using Freund's adjuvant induced arthritic model in Wistar rats revealed significant difference between both the formulations, albumin microspheres and chitosan microspheres as well as against control. It was evident from the present study that the curcumin biodegradable microspheres could be successfully employed as prolonged release drug delivery system for better therapeutic management of inflammation as compared to oral or subcutaneous route.",
author = "Virender Kumar and Lewis, {Shaila Angela} and Srinivas Mutalik and Shenoy, {Dinesh B.} and Venkatesh and N. Udupa",
year = "2002",
language = "English",
volume = "46",
pages = "209--217",
journal = "Indian Journal of Physiology and Pharmacology",
issn = "0019-5499",
publisher = "Association of Physiologists and Pharmacologists of India",
number = "2",

}

Biodegradable microspheres of curcumin for treatment of inflammation. / Kumar, Virender; Lewis, Shaila Angela; Mutalik, Srinivas; Shenoy, Dinesh B.; Venkatesh, ; Udupa, N.

In: Indian Journal of Physiology and Pharmacology, Vol. 46, No. 2, 2002, p. 209-217.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Biodegradable microspheres of curcumin for treatment of inflammation

AU - Kumar, Virender

AU - Lewis, Shaila Angela

AU - Mutalik, Srinivas

AU - Shenoy, Dinesh B.

AU - Venkatesh,

AU - Udupa, N.

PY - 2002

Y1 - 2002

N2 - Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7) was formulated as prolonged release biodegradable microspheres for treatment of inflammation. Natural biodegradable polymers, namely, bovine serum albumin and chitosan were used to encapsulate curcumin to form a depot forming drug delivery system. Microspheres were prepared by emulsion-solvent evaporation method coupled with chemical cross-linking of the natural polymers. Curcumin could be encapsulated into the biodegradable carriers upto an extent of 79.49 and 39.66% respectively with albumin and chitosan. Different drug:polymer ratios did not affect the mean particle size or particle size distribution significantly. However, the concentration of the crosslinking agent had remarkable influence on the drug release. In-vitro release studies indicated a biphasic drug release pattern, characterized by a typical burst-effect followed by a slow release which continued for several days. Evaluation of antiinflammatory activity using Freund's adjuvant induced arthritic model in Wistar rats revealed significant difference between both the formulations, albumin microspheres and chitosan microspheres as well as against control. It was evident from the present study that the curcumin biodegradable microspheres could be successfully employed as prolonged release drug delivery system for better therapeutic management of inflammation as compared to oral or subcutaneous route.

AB - Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7) was formulated as prolonged release biodegradable microspheres for treatment of inflammation. Natural biodegradable polymers, namely, bovine serum albumin and chitosan were used to encapsulate curcumin to form a depot forming drug delivery system. Microspheres were prepared by emulsion-solvent evaporation method coupled with chemical cross-linking of the natural polymers. Curcumin could be encapsulated into the biodegradable carriers upto an extent of 79.49 and 39.66% respectively with albumin and chitosan. Different drug:polymer ratios did not affect the mean particle size or particle size distribution significantly. However, the concentration of the crosslinking agent had remarkable influence on the drug release. In-vitro release studies indicated a biphasic drug release pattern, characterized by a typical burst-effect followed by a slow release which continued for several days. Evaluation of antiinflammatory activity using Freund's adjuvant induced arthritic model in Wistar rats revealed significant difference between both the formulations, albumin microspheres and chitosan microspheres as well as against control. It was evident from the present study that the curcumin biodegradable microspheres could be successfully employed as prolonged release drug delivery system for better therapeutic management of inflammation as compared to oral or subcutaneous route.

UR - http://www.scopus.com/inward/record.url?scp=0036235732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036235732&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 209

EP - 217

JO - Indian Journal of Physiology and Pharmacology

JF - Indian Journal of Physiology and Pharmacology

SN - 0019-5499

IS - 2

ER -