Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS)

V. K. Unnikrishnan, Rajesh Nayak, Sujatha Bhat, Stanley Mathew, V. B. Kartha, C. Santhosh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

LIBS has been proven to be a robust elemental analysis tool attracting interest because of the wide applications. LIBS can be used for analysis of any type of samples i.e. environmental/physiological, regardless of its state of matter. Conventional spectroscopy techniques are good in analytical performance, but their sample preparation method is mostly destructive and time consuming. Also, almost all these methods are incapable of analysing multi elements simaltaneously. On the other hand, LIBS has many potential advantages such as simplicity in the experimental setup, less sample preparation, less destructive analysis of sample etc. In this paper, we report some of the biomedical applications of LIBS. From the experiments carried out on clinical samples (calcified tissues or teeth and gall stones) for trace elemental mapping and detection, it was found that LIBS is a robust tool for such applications. It is seen that the presence and relative concentrations of major elements (calcium, phosphorus and magnesium) in human calcified tissue (tooth) can be easily determined using LIBS technique. The importance of this study comes in anthropology where tooth and bone are main samples from which reliable data can be easily retrieved. Similarly, elemental composition of bile juice and gall stone collected from the same subject using LIBS was found to be similar. The results show interesting prospects for LIBS to study cholelithiasis (the presence of stones in the gall bladder, is a common disease of the gastrointestinal tract) better.

Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing XV
Subtitle of host publicationToward Point-of-Care Diagnostics
PublisherSPIE
Volume9332
ISBN (Electronic)9781628414226
DOIs
Publication statusPublished - 01-01-2015
EventOptical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics - San Francisco, United States
Duration: 09-02-201512-02-2015

Conference

ConferenceOptical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics
CountryUnited States
CitySan Francisco
Period09-02-1512-02-15

Fingerprint

Laser induced breakdown spectroscopy
laser-induced breakdown spectroscopy
Spectrum Analysis
Lasers
gall
teeth
Gallstones
Tooth
rocks
anthropology
Tissue
juices
preparation
bladder
Cholelithiasis
Anthropology
Chemical analysis
Chemical elements
Phosphorus
Magnesium

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Unnikrishnan, V. K., Nayak, R., Bhat, S., Mathew, S., Kartha, V. B., & Santhosh, C. (2015). Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS). In Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics (Vol. 9332). [933211] SPIE. https://doi.org/10.1117/12.2080710
Unnikrishnan, V. K. ; Nayak, Rajesh ; Bhat, Sujatha ; Mathew, Stanley ; Kartha, V. B. ; Santhosh, C. / Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS). Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics. Vol. 9332 SPIE, 2015.
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Unnikrishnan, VK, Nayak, R, Bhat, S, Mathew, S, Kartha, VB & Santhosh, C 2015, Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS). in Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics. vol. 9332, 933211, SPIE, Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics, San Francisco, United States, 09-02-15. https://doi.org/10.1117/12.2080710

Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS). / Unnikrishnan, V. K.; Nayak, Rajesh; Bhat, Sujatha; Mathew, Stanley; Kartha, V. B.; Santhosh, C.

Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics. Vol. 9332 SPIE, 2015. 933211.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - LIBS has been proven to be a robust elemental analysis tool attracting interest because of the wide applications. LIBS can be used for analysis of any type of samples i.e. environmental/physiological, regardless of its state of matter. Conventional spectroscopy techniques are good in analytical performance, but their sample preparation method is mostly destructive and time consuming. Also, almost all these methods are incapable of analysing multi elements simaltaneously. On the other hand, LIBS has many potential advantages such as simplicity in the experimental setup, less sample preparation, less destructive analysis of sample etc. In this paper, we report some of the biomedical applications of LIBS. From the experiments carried out on clinical samples (calcified tissues or teeth and gall stones) for trace elemental mapping and detection, it was found that LIBS is a robust tool for such applications. It is seen that the presence and relative concentrations of major elements (calcium, phosphorus and magnesium) in human calcified tissue (tooth) can be easily determined using LIBS technique. The importance of this study comes in anthropology where tooth and bone are main samples from which reliable data can be easily retrieved. Similarly, elemental composition of bile juice and gall stone collected from the same subject using LIBS was found to be similar. The results show interesting prospects for LIBS to study cholelithiasis (the presence of stones in the gall bladder, is a common disease of the gastrointestinal tract) better.

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Unnikrishnan VK, Nayak R, Bhat S, Mathew S, Kartha VB, Santhosh C. Biomedical applications of Laser-Induced Breakdown Spectroscopy (LIBS). In Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics. Vol. 9332. SPIE. 2015. 933211 https://doi.org/10.1117/12.2080710