Blastoid variant of mantle cell lymphoma with leukemic presentation - A rare case report

Ruchee Khanna, Sushma Belurkar, P. Lavanya, Chethan Manohar, Manna Valiathan

Research output: Contribution to journalArticle

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Abstract

Mantle Cell Lymphoma (MCL) is a type of Non-Hodgkin's lymphoma and has a wide spectrum of histopathological subtypes of which the blastoid or the blastic variant constitutes 10-15% of all cases. It is difficult to diagnose blastoid variant of MCL on the basis of morphology alone as it mimics lymphoblastic lymphoma and centroblastic large cell lymphoma, hence additional analysis like immunophenotyping and molecular studies aid in its diagnosis. We present a case of 45-year-old male who presented to medicine OPD with chief complaints of fever, fatigability and inguinal swelling. Complete blood count, peripheral smear and Bone marrow examination was performed. Peripheral smear showed thrombocytopenia along with 53% abnormal cells. On bone marrow examination 43% abnormal lymphoid cells were seen. This case was diagnosed as blastoid variant of Mantle cell lymphoma on the basis of routine morphology and immunohistochemistry on bone marrow biopsy and flow cytometric immunophenotyping on peripheral blood.

Original languageEnglish
Pages (from-to)ED16-ED18
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number4
DOIs
Publication statusPublished - 01-04-2017

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Mantle-Cell Lymphoma
Bone Marrow Examination
Immunophenotyping
Bone
Blood
Blood Cell Count
Groin
Biopsy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombocytopenia
Non-Hodgkin's Lymphoma
Medicine
Swelling
Lymphoma
Fever
Bone Marrow
Immunohistochemistry
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Mantle Cell Lymphoma (MCL) is a type of Non-Hodgkin's lymphoma and has a wide spectrum of histopathological subtypes of which the blastoid or the blastic variant constitutes 10-15{\%} of all cases. It is difficult to diagnose blastoid variant of MCL on the basis of morphology alone as it mimics lymphoblastic lymphoma and centroblastic large cell lymphoma, hence additional analysis like immunophenotyping and molecular studies aid in its diagnosis. We present a case of 45-year-old male who presented to medicine OPD with chief complaints of fever, fatigability and inguinal swelling. Complete blood count, peripheral smear and Bone marrow examination was performed. Peripheral smear showed thrombocytopenia along with 53{\%} abnormal cells. On bone marrow examination 43{\%} abnormal lymphoid cells were seen. This case was diagnosed as blastoid variant of Mantle cell lymphoma on the basis of routine morphology and immunohistochemistry on bone marrow biopsy and flow cytometric immunophenotyping on peripheral blood.",
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Blastoid variant of mantle cell lymphoma with leukemic presentation - A rare case report. / Khanna, Ruchee; Belurkar, Sushma; Lavanya, P.; Manohar, Chethan; Valiathan, Manna.

In: Journal of Clinical and Diagnostic Research, Vol. 11, No. 4, 01.04.2017, p. ED16-ED18.

Research output: Contribution to journalArticle

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AB - Mantle Cell Lymphoma (MCL) is a type of Non-Hodgkin's lymphoma and has a wide spectrum of histopathological subtypes of which the blastoid or the blastic variant constitutes 10-15% of all cases. It is difficult to diagnose blastoid variant of MCL on the basis of morphology alone as it mimics lymphoblastic lymphoma and centroblastic large cell lymphoma, hence additional analysis like immunophenotyping and molecular studies aid in its diagnosis. We present a case of 45-year-old male who presented to medicine OPD with chief complaints of fever, fatigability and inguinal swelling. Complete blood count, peripheral smear and Bone marrow examination was performed. Peripheral smear showed thrombocytopenia along with 53% abnormal cells. On bone marrow examination 43% abnormal lymphoid cells were seen. This case was diagnosed as blastoid variant of Mantle cell lymphoma on the basis of routine morphology and immunohistochemistry on bone marrow biopsy and flow cytometric immunophenotyping on peripheral blood.

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