Bleomycin-induced reversible acute interstitial pneumonia

O. Balaji, D. Amita, Navin Patil, Joseph Thomas

Research output: Contribution to journalArticle

Abstract

As of now, about 380 medications are implicated in causing respiratory reactions and most common among that is drug-induced interstitial disease. Oral, parental as well inhalational drugs are known to cause drug-induced interstitial lung disease. Bleomycin is a chemotherapeutic agent used in the treatment of lymphomas, germ cell tumors of the testes. Most common pulmonary toxicity is diffuse alveolar damage with nonspecific interstitial pneumonitis being next. We report a case of bleomycin-induced reversible acute interstitial pneumonia in a Hodgkin’s lymphoma patient with adriamycin, bleomycin, vinblastine, dacarbazine regimen. Causality assessment was done using Naranjo scale, and probable causal relationship was established. Adverse drug reaction was found to be moderately severe and not preventable as per Hartwig’s severity and Thornton’s preventability scaling respectively.

Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number5
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Interstitial Lung Diseases
Bleomycin
Pharmaceutical Preparations
Dacarbazine
Vinblastine
Germ Cell and Embryonal Neoplasms
Drug-Related Side Effects and Adverse Reactions
Hodgkin Disease
Causality
Doxorubicin
Testis
Lymphoma
Lung
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

@article{e6553e9208d84a36be238787fa743e9f,
title = "Bleomycin-induced reversible acute interstitial pneumonia",
abstract = "As of now, about 380 medications are implicated in causing respiratory reactions and most common among that is drug-induced interstitial disease. Oral, parental as well inhalational drugs are known to cause drug-induced interstitial lung disease. Bleomycin is a chemotherapeutic agent used in the treatment of lymphomas, germ cell tumors of the testes. Most common pulmonary toxicity is diffuse alveolar damage with nonspecific interstitial pneumonitis being next. We report a case of bleomycin-induced reversible acute interstitial pneumonia in a Hodgkin’s lymphoma patient with adriamycin, bleomycin, vinblastine, dacarbazine regimen. Causality assessment was done using Naranjo scale, and probable causal relationship was established. Adverse drug reaction was found to be moderately severe and not preventable as per Hartwig’s severity and Thornton’s preventability scaling respectively.",
author = "O. Balaji and D. Amita and Navin Patil and Joseph Thomas",
year = "2017",
month = "1",
day = "1",
doi = "10.22159/ajpcr.2017.v10i5.17121",
language = "English",
volume = "10",
pages = "6--8",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "5",

}

Bleomycin-induced reversible acute interstitial pneumonia. / Balaji, O.; Amita, D.; Patil, Navin; Thomas, Joseph.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 5, 01.01.2017, p. 6-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bleomycin-induced reversible acute interstitial pneumonia

AU - Balaji, O.

AU - Amita, D.

AU - Patil, Navin

AU - Thomas, Joseph

PY - 2017/1/1

Y1 - 2017/1/1

N2 - As of now, about 380 medications are implicated in causing respiratory reactions and most common among that is drug-induced interstitial disease. Oral, parental as well inhalational drugs are known to cause drug-induced interstitial lung disease. Bleomycin is a chemotherapeutic agent used in the treatment of lymphomas, germ cell tumors of the testes. Most common pulmonary toxicity is diffuse alveolar damage with nonspecific interstitial pneumonitis being next. We report a case of bleomycin-induced reversible acute interstitial pneumonia in a Hodgkin’s lymphoma patient with adriamycin, bleomycin, vinblastine, dacarbazine regimen. Causality assessment was done using Naranjo scale, and probable causal relationship was established. Adverse drug reaction was found to be moderately severe and not preventable as per Hartwig’s severity and Thornton’s preventability scaling respectively.

AB - As of now, about 380 medications are implicated in causing respiratory reactions and most common among that is drug-induced interstitial disease. Oral, parental as well inhalational drugs are known to cause drug-induced interstitial lung disease. Bleomycin is a chemotherapeutic agent used in the treatment of lymphomas, germ cell tumors of the testes. Most common pulmonary toxicity is diffuse alveolar damage with nonspecific interstitial pneumonitis being next. We report a case of bleomycin-induced reversible acute interstitial pneumonia in a Hodgkin’s lymphoma patient with adriamycin, bleomycin, vinblastine, dacarbazine regimen. Causality assessment was done using Naranjo scale, and probable causal relationship was established. Adverse drug reaction was found to be moderately severe and not preventable as per Hartwig’s severity and Thornton’s preventability scaling respectively.

UR - http://www.scopus.com/inward/record.url?scp=85018724346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018724346&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2017.v10i5.17121

DO - 10.22159/ajpcr.2017.v10i5.17121

M3 - Article

VL - 10

SP - 6

EP - 8

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 5

ER -