Abstract

Thalassemia is a group of disorders characterized by deficient production of the ß-globin sub unit of hemoglobin. The mandatory blood transfusions in patients with thalassemia to maintain adequate erythrocyte levels, leads to iron overload. The prevalence of diabetes in patients with thalassemia varies from 6 to 14%. We here by present a known case of thalassemia major in an 18 year old boy. He was diagnosed with thalassemia before the age of one year and is on regular blood transfusion every two weeks since then. The repeated blood transfusion is one of the common causes for haemochromatosis. Iron overload initially leads to glucose abnormalities such as insulin resistance and hyperinsulinemia, which is followed by impaired secretion of insulin. Diagnosed as a case of bronze diabetes, this patient is on insulin therapy for the last two years. Currently the patient is on iron chelation therapy at Kasturba Medical College Hospital, Mangalore, Karnataka, India.

Original languageEnglish
Pages (from-to)BD01-BD02
JournalJournal of Clinical and Diagnostic Research
Volume9
Issue number4
DOIs
Publication statusPublished - 01-04-2015

Fingerprint

Thalassemia
Hemochromatosis
Bronze
Medical problems
Blood
Iron
Blood Transfusion
Insulin
Iron Overload
Globins
Chelation Therapy
Chelation
beta-Thalassemia
Hyperinsulinism
Hemoglobins
Insulin Resistance
Glucose
India
Erythrocytes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Akshatha, L. N. ; Shenoy, Mamatha T. ; Yadav, Charu ; Rukmini, M. S. ; Kamath, Nutan. / Bronze diabetes. In: Journal of Clinical and Diagnostic Research. 2015 ; Vol. 9, No. 4. pp. BD01-BD02.
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Bronze diabetes. / Akshatha, L. N.; Shenoy, Mamatha T.; Yadav, Charu; Rukmini, M. S.; Kamath, Nutan.

In: Journal of Clinical and Diagnostic Research, Vol. 9, No. 4, 01.04.2015, p. BD01-BD02.

Research output: Contribution to journalArticle

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AU - Akshatha, L. N.

AU - Shenoy, Mamatha T.

AU - Yadav, Charu

AU - Rukmini, M. S.

AU - Kamath, Nutan

PY - 2015/4/1

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AB - Thalassemia is a group of disorders characterized by deficient production of the ß-globin sub unit of hemoglobin. The mandatory blood transfusions in patients with thalassemia to maintain adequate erythrocyte levels, leads to iron overload. The prevalence of diabetes in patients with thalassemia varies from 6 to 14%. We here by present a known case of thalassemia major in an 18 year old boy. He was diagnosed with thalassemia before the age of one year and is on regular blood transfusion every two weeks since then. The repeated blood transfusion is one of the common causes for haemochromatosis. Iron overload initially leads to glucose abnormalities such as insulin resistance and hyperinsulinemia, which is followed by impaired secretion of insulin. Diagnosed as a case of bronze diabetes, this patient is on insulin therapy for the last two years. Currently the patient is on iron chelation therapy at Kasturba Medical College Hospital, Mangalore, Karnataka, India.

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