Introduction: Brown tumors are focal bone lesions that occur in hyperparathyroidism. These tumors occur in any part of the skeleton but craniofacial involvement is rare. Case Report: We report a case of a 26-year-old male with a known history of chronic kidney disease who reported with a complaint of a painless, slow growing, swelling on the left side of lower face. Blood picture revealed extremely elevated levels of parathyroid hormone. Panoramic radiograph showed a well-defined, unilocular radiolucency in the posterior mandible. Discussion: Skeletal involvement due to secondary hyperparathyroidism is a well-known phenomenon. Involvement of the crani-ofacial skeleton is rare and the jaw bones is even rarer. Brown tumor of hyperparathyroidism is a slow growing, self-limiting lesions and resolves as the systemic condition improves. Conclusion: It is important that dentists are aware and alert about this untoward pathology secondary to the coexisting comor-bidities of CKD.
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