Burkholderia cepacia sepsis among neonates

Saikat Patra, Ramesh Y. Bhat, Leslie Edward Lewis, Jayashree Purakayastha, V. Vamsi Sivaramaraju, Vandana Kalwaje E, Swathi Mishra

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7%) were major presenting features. Five newborns (41.7%) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100%), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83%), ceftazidime (75%) and ciprofloxacin (42%). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7%) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalIndian Journal of Pediatrics
Volume81
Issue number11
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Burkholderia cepacia
Sepsis
Newborn Infant
Burkholderia Infections
meropenem
Sulfamethoxazole Drug Combination Trimethoprim
Ciprofloxacin
Anti-Bacterial Agents
Cefoperazone
Sulbactam
Lethargy
Ceftazidime
Disinfectants
Hydrocephalus
Artificial Respiration
Epidemiology
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Patra, S., Bhat, R. Y., Lewis, L. E., Purakayastha, J., Vamsi Sivaramaraju, V., Kalwaje E, V., & Mishra, S. (2014). Burkholderia cepacia sepsis among neonates. Indian Journal of Pediatrics, 81(11), 1233-1236. https://doi.org/10.1007/s12098-014-1473-9
Patra, Saikat ; Bhat, Ramesh Y. ; Lewis, Leslie Edward ; Purakayastha, Jayashree ; Vamsi Sivaramaraju, V. ; Kalwaje E, Vandana ; Mishra, Swathi. / Burkholderia cepacia sepsis among neonates. In: Indian Journal of Pediatrics. 2014 ; Vol. 81, No. 11. pp. 1233-1236.
@article{495a75af23954afa8046591a68ae50e5,
title = "Burkholderia cepacia sepsis among neonates",
abstract = "Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7{\%}) were major presenting features. Five newborns (41.7{\%}) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100{\%}), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83{\%}), ceftazidime (75{\%}) and ciprofloxacin (42{\%}). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7{\%}) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.",
author = "Saikat Patra and Bhat, {Ramesh Y.} and Lewis, {Leslie Edward} and Jayashree Purakayastha and {Vamsi Sivaramaraju}, V. and {Kalwaje E}, Vandana and Swathi Mishra",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s12098-014-1473-9",
language = "English",
volume = "81",
pages = "1233--1236",
journal = "Indian Journal of Practical Pediatrics",
issn = "0972-9607",
publisher = "Springer India",
number = "11",

}

Patra, S, Bhat, RY, Lewis, LE, Purakayastha, J, Vamsi Sivaramaraju, V, Kalwaje E, V & Mishra, S 2014, 'Burkholderia cepacia sepsis among neonates', Indian Journal of Pediatrics, vol. 81, no. 11, pp. 1233-1236. https://doi.org/10.1007/s12098-014-1473-9

Burkholderia cepacia sepsis among neonates. / Patra, Saikat; Bhat, Ramesh Y.; Lewis, Leslie Edward; Purakayastha, Jayashree; Vamsi Sivaramaraju, V.; Kalwaje E, Vandana; Mishra, Swathi.

In: Indian Journal of Pediatrics, Vol. 81, No. 11, 01.01.2014, p. 1233-1236.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Burkholderia cepacia sepsis among neonates

AU - Patra, Saikat

AU - Bhat, Ramesh Y.

AU - Lewis, Leslie Edward

AU - Purakayastha, Jayashree

AU - Vamsi Sivaramaraju, V.

AU - Kalwaje E, Vandana

AU - Mishra, Swathi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7%) were major presenting features. Five newborns (41.7%) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100%), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83%), ceftazidime (75%) and ciprofloxacin (42%). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7%) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.

AB - Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7%) were major presenting features. Five newborns (41.7%) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100%), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83%), ceftazidime (75%) and ciprofloxacin (42%). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7%) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.

UR - http://www.scopus.com/inward/record.url?scp=84948384796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948384796&partnerID=8YFLogxK

U2 - 10.1007/s12098-014-1473-9

DO - 10.1007/s12098-014-1473-9

M3 - Article

VL - 81

SP - 1233

EP - 1236

JO - Indian Journal of Practical Pediatrics

JF - Indian Journal of Practical Pediatrics

SN - 0972-9607

IS - 11

ER -

Patra S, Bhat RY, Lewis LE, Purakayastha J, Vamsi Sivaramaraju V, Kalwaje E V et al. Burkholderia cepacia sepsis among neonates. Indian Journal of Pediatrics. 2014 Jan 1;81(11):1233-1236. https://doi.org/10.1007/s12098-014-1473-9