Burkholderia pseudomallei musculoskeletal infections (melioidosis) in India

Vivek Pandey, Sripathi P. Rao, Sugandhi Rao, Kiran V. Acharya, Sarabjeet Singh Chhabra

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Melioidosis, an infection due to gram negative Burkholderia pseudomallei, is an important cause of sepsis in east Asia especially Thailand and northern Australia. It usually causes abscesses in lung, liver, spleen, skeletal muscle and parotids especially in patients with diabetes, chronic renal failure and thalassemia. Musculoskeletal melioidosis is not common in India even though sporadic cases have been reported mostly involving soft tissues. During a two-year-period, we had five patients with musculoskeletal melioidosis. All patients presented with multifocal osteomyelitis, recurrent osteomyelitis or septic arthritis. One patient died early because of septicemia and multi-organ failure. All patients were diagnosed on the basis of positive pus culture. All patients were treated by surgical debridement followed by a combination of antibiotics; (ceftazidime, amoxy-clavulanic acid, co-trimoxazole and doxycycline) for six months except for one who died due to fulminant septicemia. All other patients recovered completely with no recurrences. With increasing awareness and better diagnostic facilities, probably musculoskeletal melioidosis will be increasingly diagnosed in future.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalIndian Journal of Orthopaedics
Volume44
Issue number2
DOIs
Publication statusPublished - 01-04-2010

Fingerprint

Melioidosis
Burkholderia pseudomallei
India
Infection
Sepsis
Osteomyelitis
Lung Abscess
Clavulanic Acid
Infectious Arthritis
Thalassemia
Ceftazidime
Far East
Suppuration
Doxycycline
Sulfamethoxazole Drug Combination Trimethoprim
Debridement
Thailand
Chronic Kidney Failure
Skeletal Muscle
Spleen

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Pandey, Vivek ; Rao, Sripathi P. ; Rao, Sugandhi ; Acharya, Kiran V. ; Chhabra, Sarabjeet Singh. / Burkholderia pseudomallei musculoskeletal infections (melioidosis) in India. In: Indian Journal of Orthopaedics. 2010 ; Vol. 44, No. 2. pp. 216-220.
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Burkholderia pseudomallei musculoskeletal infections (melioidosis) in India. / Pandey, Vivek; Rao, Sripathi P.; Rao, Sugandhi; Acharya, Kiran V.; Chhabra, Sarabjeet Singh.

In: Indian Journal of Orthopaedics, Vol. 44, No. 2, 01.04.2010, p. 216-220.

Research output: Contribution to journalArticle

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