Cadherins in cardiovascular disease

Therese J. Resink, Maria Philippova, Manjunath B. Joshi, Emmanouil Kyriakakis, Paul Erne

    Research output: Contribution to journalReview article

    27 Citations (Scopus)

    Abstract

    Cardiovascular diseases encompass an enormous range of conditions arising through an equally diverse aetiology. The cadherin superfamily of cell surface adhesion molecules have long been recognised for their crucial roles in morphogenesis and controlled growth and turnover in adult tissues. Thus, their involvement in the development of cardiovascular diseases characterised by tissue remodelling can be predicted. However, given the diversity of cadherins expressed on resident cells in cardiac and vascular tissue and their assorted and frequently overlapping functions that extend beyond mere mediation of adhesive interactions, definition of specific roles in the progression of cardiovascular diseases can be confounding. Compared with the fields of embryogenesis and oncology, investigations targeted specifically toward delineation of the participation of cadherins in cardiovascular disease are remarkably scant. In this article we offer the reader a brief introduction to members of the cadherin superfamily, and review the involvement of cadherins in cardiac diseases (dilated and dysplastic cardiomyopathies) and vascular diseases (atherosclerosis and restenosis) in which prominent alterations in tissue architecture occur and ultimately cause the clinical manifestations and complications of the diseases. Putative functions of the different cadherins expressed in cardiomyocytes, smooth muscle cells and endothelial cells are discussed.

    Original languageEnglish
    Pages (from-to)122-134
    Number of pages13
    JournalSwiss Medical Weekly
    Volume139
    Issue number9-10
    Publication statusPublished - 06-03-2009

    Fingerprint

    Cadherins
    Cardiovascular Diseases
    Cell Adhesion Molecules
    Dilated Cardiomyopathy
    Vascular Diseases
    Morphogenesis
    Cardiac Myocytes
    Adhesives
    Smooth Muscle Myocytes
    Embryonic Development
    Blood Vessels
    Heart Diseases
    Atherosclerosis
    Endothelial Cells
    Growth

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    Cite this

    Resink, T. J., Philippova, M., Joshi, M. B., Kyriakakis, E., & Erne, P. (2009). Cadherins in cardiovascular disease. Swiss Medical Weekly, 139(9-10), 122-134.
    Resink, Therese J. ; Philippova, Maria ; Joshi, Manjunath B. ; Kyriakakis, Emmanouil ; Erne, Paul. / Cadherins in cardiovascular disease. In: Swiss Medical Weekly. 2009 ; Vol. 139, No. 9-10. pp. 122-134.
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    Resink, TJ, Philippova, M, Joshi, MB, Kyriakakis, E & Erne, P 2009, 'Cadherins in cardiovascular disease', Swiss Medical Weekly, vol. 139, no. 9-10, pp. 122-134.

    Cadherins in cardiovascular disease. / Resink, Therese J.; Philippova, Maria; Joshi, Manjunath B.; Kyriakakis, Emmanouil; Erne, Paul.

    In: Swiss Medical Weekly, Vol. 139, No. 9-10, 06.03.2009, p. 122-134.

    Research output: Contribution to journalReview article

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    Resink TJ, Philippova M, Joshi MB, Kyriakakis E, Erne P. Cadherins in cardiovascular disease. Swiss Medical Weekly. 2009 Mar 6;139(9-10):122-134.