Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

Sanchari Basu Mallik, Jayesh Mudgal, Madhavan Nampoothiri, Susan Hall, Shailendra Anoopkumar Dukie, Gary Grant, C. Mallikarjuna Rao, Devinder Arora

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalNeuroscience Letters
Volume632
DOIs
Publication statusPublished - 06-10-2016

Fingerprint

Illness Behavior
Lipopolysaccharides
Brain
Oxidative Stress
Antioxidants
Cytokines
Imipramine
Major Depressive Disorder
Polyphenols
Oxidants
caffeic acid
Immune System
Anti-Inflammatory Agents
Biomarkers
Depression
Inflammation
Injections
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Basu Mallik, Sanchari ; Mudgal, Jayesh ; Nampoothiri, Madhavan ; Hall, Susan ; Dukie, Shailendra Anoopkumar ; Grant, Gary ; Rao, C. Mallikarjuna ; Arora, Devinder. / Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice. In: Neuroscience Letters. 2016 ; Vol. 632. pp. 218-223.
@article{6d66d4061dfa4db0bd864e75330be6bc,
title = "Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice",
abstract = "Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.",
author = "{Basu Mallik}, Sanchari and Jayesh Mudgal and Madhavan Nampoothiri and Susan Hall and Dukie, {Shailendra Anoopkumar} and Gary Grant and Rao, {C. Mallikarjuna} and Devinder Arora",
year = "2016",
month = "10",
day = "6",
doi = "10.1016/j.neulet.2016.08.044",
language = "English",
volume = "632",
pages = "218--223",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice. / Basu Mallik, Sanchari; Mudgal, Jayesh; Nampoothiri, Madhavan; Hall, Susan; Dukie, Shailendra Anoopkumar; Grant, Gary; Rao, C. Mallikarjuna; Arora, Devinder.

In: Neuroscience Letters, Vol. 632, 06.10.2016, p. 218-223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

AU - Basu Mallik, Sanchari

AU - Mudgal, Jayesh

AU - Nampoothiri, Madhavan

AU - Hall, Susan

AU - Dukie, Shailendra Anoopkumar

AU - Grant, Gary

AU - Rao, C. Mallikarjuna

AU - Arora, Devinder

PY - 2016/10/6

Y1 - 2016/10/6

N2 - Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.

AB - Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.

UR - http://www.scopus.com/inward/record.url?scp=84987642023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987642023&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2016.08.044

DO - 10.1016/j.neulet.2016.08.044

M3 - Article

VL - 632

SP - 218

EP - 223

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -