Cardiac enzymes, total thiols and lipid peroxidation in patients with acute myocardial infarction

Babu Suresh, Jeevan Kumar Shetty, Mungli Prakash

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Oxidative stress has been implicated in the pathogenesis of acute myocardial infarction. In the current work, we have measured malondialdehyde (MDA), total thiols, total creatine kinase (CK), creatine kinase-MB isoenzyme (CK-MB) and aspartate aminotransferase (AST) in electrocardiogram (ECG) proven acute myocardial infarction (AMI) patients at 12 hours after the onset of chest pain and also in healthy controls. Methods: Blood samples from 25 AMI patients and 25 age and sex matched healthy controls were obtained for the measurement of cardiac enzymes like total CK, CK-MB and AST by using an automated analyzer. Serum MDA and total thiols were determined by using spectrophotometric methods. Results: We have found a significant increase in MDA, total CK, CK-MB and AST (p< 0.001) and a significant decrease in total thiols (p<0.001) in AMI patients as compared to the healthy controls. MDA correlated negatively with total thiols (r = - 0.573, p<0.01) and positively with CK-MB (r = 0.845, p<0.01) and AST (r = 0.676, p<0.01) in the AMI patients. Conclusions: Reactive oxygen species play a role in the pathogenesis of atherosclerosis, thus leading to acute coronary events and their levels are further elevated by the ischaemic event itself.

Original languageEnglish
Pages (from-to)3425-3429
Number of pages5
JournalJournal of Clinical and Diagnostic Research
Volume4
Issue number6
Publication statusPublished - 30-12-2010
Externally publishedYes

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MB Form Creatine Kinase
Aspartate Aminotransferases
Malondialdehyde
Sulfhydryl Compounds
Lipid Peroxidation
Creatine Kinase
Myocardial Infarction
Lipids
Enzymes
Oxidative stress
Electrocardiography
Isoenzymes
Reactive Oxygen Species
Chest Pain
Blood
Atherosclerosis
Oxidative Stress
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Suresh, Babu ; Shetty, Jeevan Kumar ; Prakash, Mungli. / Cardiac enzymes, total thiols and lipid peroxidation in patients with acute myocardial infarction. In: Journal of Clinical and Diagnostic Research. 2010 ; Vol. 4, No. 6. pp. 3425-3429.
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Cardiac enzymes, total thiols and lipid peroxidation in patients with acute myocardial infarction. / Suresh, Babu; Shetty, Jeevan Kumar; Prakash, Mungli.

In: Journal of Clinical and Diagnostic Research, Vol. 4, No. 6, 30.12.2010, p. 3425-3429.

Research output: Contribution to journalArticle

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