Sudden cardiac death is a primary cause of mortality in patients with cardiovascular diseases, is caused by the loss of regular cardiac rhythm. In the present study 1, 3-oxazolidines were synthesized and their physiochemical parameters like melting point, retardation factor were analyzed. All the compounds were screened for their antiarrhythmic activity by calcium chloride- induced arrhythmias in isolated frog heart at graded dose level. Compounds 4-[3-(2-furylmethyl)-4-phenyl-1,3-oxazolidin-2-yl]-2-methoxy phenol (8), 4-[3-(2-furylmethyl)-4-phenyl-1,3-oxazolidin-2-yl]phenol (9) and 2-(4-chlorophenyl)-3-(2-furylmethyl)-4-phenyl-1, 3-oxazolidine (10) showed very good negative chronotropic and inotropic effect by blocking the calcium entry. All other compounds showed moderate activity. Compounds containing 4-hydroxy and 3-methoxy, 4-hydroxy and 4-chloro substitutions were found to increase the antiarrhythmic activity.
|Number of pages||8|
|Publication status||Published - 2008|