Cardioprotective effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 955 and DPJ 890 against isoprenaline induced myocardial necrosis

K. Nandakumar, Sachin Bansal, Lokesh Kumar Bhatt, Subhash L. Bodhankar, Vikram S. Ghole, Mohane S. Coumar, Dharm P. Jindal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Two newly synthesized blockers, DPJ 955 and DPJ 890 were studied for cardioprotective action against isoprenaline induced myocardial necrosis and anti lipid peroxidation potential against ferric chloride induced lipid peroxidation. Administration of isoprenaline (300 mg/kg, s.c.) for 3 days at an interval of 24 hours significantly increased LDH, CK, AST and ALT levels as compared to normal animals. Treatment with DPJ 955 (10 mg/kg) and DPJ 890 (3 mg/kg) for 4 days followed by administration of isoprenaline (300mg/kg, s.c.) for a period of 3 days significantly reduced the concentration of marker enzymes in serum. Histological examination of hearts revealed that DPJ 890 (3 mg/kg, i.p.) reduced the severity of infarction produced by isoprenaline. The mortality was found to be very high (50%) with isoprenaline alone treated group. Pretreatment with DPJ 955 (10 mg/kg), DPJ 890 (3 mg/kg) reduced the mortality rate as compared to isoprenaline treated group. The cardioprotective effect produced by DPJ 890 was superior to propranolol. DPJ 955, DPJ 890, propranolol and carvedilol produced concentration dependent reduction in lipid peroxidation induced by ferric chloride. The rank order potency of anti lipid peroxidation activity was found to be carvedilol > DPJ 955 > propranolol = DPJ 890. These results suggest that prevention of myocardial damage produced by isoprenaline in rats pretreated with DPJ 955, DPJ 890 and propranolol may be mainly due to the blocking activity as these compounds lacked lipid peroxidation activity.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalToxicology International
Volume12
Issue number2
Publication statusPublished - 01-12-2005

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Propanolamines
Isoproterenol
Necrosis
Derivatives
Lipid Peroxidation
Propranolol
Lipids
Mortality
DPJ 890
DPJ 955
Infarction
Rats
Animals

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Nandakumar, K. ; Bansal, Sachin ; Bhatt, Lokesh Kumar ; Bodhankar, Subhash L. ; Ghole, Vikram S. ; Coumar, Mohane S. ; Jindal, Dharm P. / Cardioprotective effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 955 and DPJ 890 against isoprenaline induced myocardial necrosis. In: Toxicology International. 2005 ; Vol. 12, No. 2. pp. 61-66.
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abstract = "Two newly synthesized blockers, DPJ 955 and DPJ 890 were studied for cardioprotective action against isoprenaline induced myocardial necrosis and anti lipid peroxidation potential against ferric chloride induced lipid peroxidation. Administration of isoprenaline (300 mg/kg, s.c.) for 3 days at an interval of 24 hours significantly increased LDH, CK, AST and ALT levels as compared to normal animals. Treatment with DPJ 955 (10 mg/kg) and DPJ 890 (3 mg/kg) for 4 days followed by administration of isoprenaline (300mg/kg, s.c.) for a period of 3 days significantly reduced the concentration of marker enzymes in serum. Histological examination of hearts revealed that DPJ 890 (3 mg/kg, i.p.) reduced the severity of infarction produced by isoprenaline. The mortality was found to be very high (50{\%}) with isoprenaline alone treated group. Pretreatment with DPJ 955 (10 mg/kg), DPJ 890 (3 mg/kg) reduced the mortality rate as compared to isoprenaline treated group. The cardioprotective effect produced by DPJ 890 was superior to propranolol. DPJ 955, DPJ 890, propranolol and carvedilol produced concentration dependent reduction in lipid peroxidation induced by ferric chloride. The rank order potency of anti lipid peroxidation activity was found to be carvedilol > DPJ 955 > propranolol = DPJ 890. These results suggest that prevention of myocardial damage produced by isoprenaline in rats pretreated with DPJ 955, DPJ 890 and propranolol may be mainly due to the blocking activity as these compounds lacked lipid peroxidation activity.",
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Cardioprotective effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 955 and DPJ 890 against isoprenaline induced myocardial necrosis. / Nandakumar, K.; Bansal, Sachin; Bhatt, Lokesh Kumar; Bodhankar, Subhash L.; Ghole, Vikram S.; Coumar, Mohane S.; Jindal, Dharm P.

In: Toxicology International, Vol. 12, No. 2, 01.12.2005, p. 61-66.

Research output: Contribution to journalArticle

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T1 - Cardioprotective effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 955 and DPJ 890 against isoprenaline induced myocardial necrosis

AU - Nandakumar, K.

AU - Bansal, Sachin

AU - Bhatt, Lokesh Kumar

AU - Bodhankar, Subhash L.

AU - Ghole, Vikram S.

AU - Coumar, Mohane S.

AU - Jindal, Dharm P.

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N2 - Two newly synthesized blockers, DPJ 955 and DPJ 890 were studied for cardioprotective action against isoprenaline induced myocardial necrosis and anti lipid peroxidation potential against ferric chloride induced lipid peroxidation. Administration of isoprenaline (300 mg/kg, s.c.) for 3 days at an interval of 24 hours significantly increased LDH, CK, AST and ALT levels as compared to normal animals. Treatment with DPJ 955 (10 mg/kg) and DPJ 890 (3 mg/kg) for 4 days followed by administration of isoprenaline (300mg/kg, s.c.) for a period of 3 days significantly reduced the concentration of marker enzymes in serum. Histological examination of hearts revealed that DPJ 890 (3 mg/kg, i.p.) reduced the severity of infarction produced by isoprenaline. The mortality was found to be very high (50%) with isoprenaline alone treated group. Pretreatment with DPJ 955 (10 mg/kg), DPJ 890 (3 mg/kg) reduced the mortality rate as compared to isoprenaline treated group. The cardioprotective effect produced by DPJ 890 was superior to propranolol. DPJ 955, DPJ 890, propranolol and carvedilol produced concentration dependent reduction in lipid peroxidation induced by ferric chloride. The rank order potency of anti lipid peroxidation activity was found to be carvedilol > DPJ 955 > propranolol = DPJ 890. These results suggest that prevention of myocardial damage produced by isoprenaline in rats pretreated with DPJ 955, DPJ 890 and propranolol may be mainly due to the blocking activity as these compounds lacked lipid peroxidation activity.

AB - Two newly synthesized blockers, DPJ 955 and DPJ 890 were studied for cardioprotective action against isoprenaline induced myocardial necrosis and anti lipid peroxidation potential against ferric chloride induced lipid peroxidation. Administration of isoprenaline (300 mg/kg, s.c.) for 3 days at an interval of 24 hours significantly increased LDH, CK, AST and ALT levels as compared to normal animals. Treatment with DPJ 955 (10 mg/kg) and DPJ 890 (3 mg/kg) for 4 days followed by administration of isoprenaline (300mg/kg, s.c.) for a period of 3 days significantly reduced the concentration of marker enzymes in serum. Histological examination of hearts revealed that DPJ 890 (3 mg/kg, i.p.) reduced the severity of infarction produced by isoprenaline. The mortality was found to be very high (50%) with isoprenaline alone treated group. Pretreatment with DPJ 955 (10 mg/kg), DPJ 890 (3 mg/kg) reduced the mortality rate as compared to isoprenaline treated group. The cardioprotective effect produced by DPJ 890 was superior to propranolol. DPJ 955, DPJ 890, propranolol and carvedilol produced concentration dependent reduction in lipid peroxidation induced by ferric chloride. The rank order potency of anti lipid peroxidation activity was found to be carvedilol > DPJ 955 > propranolol = DPJ 890. These results suggest that prevention of myocardial damage produced by isoprenaline in rats pretreated with DPJ 955, DPJ 890 and propranolol may be mainly due to the blocking activity as these compounds lacked lipid peroxidation activity.

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