CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

L. C. Silva, F. P. Fonseca, O. P. Almeida, B. A. Mariz, M. A. Lopes, R. Radhakrishnan, M. Sharma, L. P. Kowalski, P. A. Vargas

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSION: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.

Original languageEnglish
Pages (from-to)e49-e55
JournalMedicina Oral, Patologia Oral y Cirugia Bucal
Volume25
Issue number1
DOIs
Publication statusPublished - 01-01-2020

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Oral Submucous Fibrosis
Squamous Cell Carcinoma
Oral Leukoplakia
Epithelium
Dendritic Cells
Langerhans Cells

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Silva, L. C. ; Fonseca, F. P. ; Almeida, O. P. ; Mariz, B. A. ; Lopes, M. A. ; Radhakrishnan, R. ; Sharma, M. ; Kowalski, L. P. ; Vargas, P. A. / CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma. In: Medicina Oral, Patologia Oral y Cirugia Bucal. 2020 ; Vol. 25, No. 1. pp. e49-e55.
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abstract = "BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSION: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.",
author = "Silva, {L. C.} and Fonseca, {F. P.} and Almeida, {O. P.} and Mariz, {B. A.} and Lopes, {M. A.} and R. Radhakrishnan and M. Sharma and Kowalski, {L. P.} and Vargas, {P. A.}",
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Silva, LC, Fonseca, FP, Almeida, OP, Mariz, BA, Lopes, MA, Radhakrishnan, R, Sharma, M, Kowalski, LP & Vargas, PA 2020, 'CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma', Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 25, no. 1, pp. e49-e55. https://doi.org/10.4317/medoral.23177

CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma. / Silva, L. C.; Fonseca, F. P.; Almeida, O. P.; Mariz, B. A.; Lopes, M. A.; Radhakrishnan, R.; Sharma, M.; Kowalski, L. P.; Vargas, P. A.

In: Medicina Oral, Patologia Oral y Cirugia Bucal, Vol. 25, No. 1, 01.01.2020, p. e49-e55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

AU - Silva, L. C.

AU - Fonseca, F. P.

AU - Almeida, O. P.

AU - Mariz, B. A.

AU - Lopes, M. A.

AU - Radhakrishnan, R.

AU - Sharma, M.

AU - Kowalski, L. P.

AU - Vargas, P. A.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSION: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.

AB - BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSION: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.

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