Cefoperazone induced gastrointestinal bleeding

Goutham Reddy Katukuri, Raja Naga Mahesh Maddala, Kusugodlu Ramamoorthi, Manjunatha Hande

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.

Original languageEnglish
Pages (from-to)OD10-OD11
JournalJournal of Clinical and Diagnostic Research
Volume10
Issue number8
DOIs
Publication statusPublished - 01-08-2016

Fingerprint

Cefoperazone
Hemorrhage
Vitamin K
beta-Lactams
Coagulation
Metabolism
Substance-Related Disorders
Anti-Bacterial Agents
Infection
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Katukuri, Goutham Reddy ; Maddala, Raja Naga Mahesh ; Ramamoorthi, Kusugodlu ; Hande, Manjunatha. / Cefoperazone induced gastrointestinal bleeding. In: Journal of Clinical and Diagnostic Research. 2016 ; Vol. 10, No. 8. pp. OD10-OD11.
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Cefoperazone induced gastrointestinal bleeding. / Katukuri, Goutham Reddy; Maddala, Raja Naga Mahesh; Ramamoorthi, Kusugodlu; Hande, Manjunatha.

In: Journal of Clinical and Diagnostic Research, Vol. 10, No. 8, 01.08.2016, p. OD10-OD11.

Research output: Contribution to journalArticle

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