Central giant cell granuloma

An uncommon presentation

Adarsh Kudva, K. M. Cariappa, Vasantha Dhara, Monica Solomon

Research output: Contribution to journalArticle

Abstract

Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. It commonly occurs in anterior mandible with a female prediction in ages below 30yrs. Multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention. Surgical treatment has been the traditional accepted modality reducing chances of recurrence. Non-surgical treatments with alpha interferon (a-IFN), calcitonin, Denosumab and corticosteroids have been described in literature as adjuvants or as definitive treatments. This case report reviews presentation and currently used therapies for CGCG while describing a uncommon case of central giant cell granuloma occurring in a 45 year old female who presented with a swelling in relation to the left edentulous mandible. Surgical curettage of the lesion along with reconstruction and local delivery of steroid in the cavity was done allowing for the best esthetic and functional result with no recurrence during follow up.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalOral and Maxillofacial Surgery Cases
Volume4
Issue number4
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

Giant Cell Granuloma
Mandible
Recurrence
Curettage
Calcitonin
Jaw
Esthetics
Interferon-alpha
Adrenal Cortex Hormones
Steroids
Therapeutics
Neoplasms
Denosumab

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

@article{112f39f325bd4bb18f33eac3021f2c1e,
title = "Central giant cell granuloma: An uncommon presentation",
abstract = "Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7{\%} of all benign tumors of the jaws. It commonly occurs in anterior mandible with a female prediction in ages below 30yrs. Multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention. Surgical treatment has been the traditional accepted modality reducing chances of recurrence. Non-surgical treatments with alpha interferon (a-IFN), calcitonin, Denosumab and corticosteroids have been described in literature as adjuvants or as definitive treatments. This case report reviews presentation and currently used therapies for CGCG while describing a uncommon case of central giant cell granuloma occurring in a 45 year old female who presented with a swelling in relation to the left edentulous mandible. Surgical curettage of the lesion along with reconstruction and local delivery of steroid in the cavity was done allowing for the best esthetic and functional result with no recurrence during follow up.",
author = "Adarsh Kudva and Cariappa, {K. M.} and Vasantha Dhara and Monica Solomon",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.omsc.2018.08.001",
language = "English",
volume = "4",
pages = "135--140",
journal = "Oral and Maxillofacial Surgery Cases",
issn = "2214-5419",
publisher = "Elsevier BV",
number = "4",

}

Central giant cell granuloma : An uncommon presentation. / Kudva, Adarsh; Cariappa, K. M.; Dhara, Vasantha; Solomon, Monica.

In: Oral and Maxillofacial Surgery Cases, Vol. 4, No. 4, 01.12.2018, p. 135-140.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Central giant cell granuloma

T2 - An uncommon presentation

AU - Kudva, Adarsh

AU - Cariappa, K. M.

AU - Dhara, Vasantha

AU - Solomon, Monica

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. It commonly occurs in anterior mandible with a female prediction in ages below 30yrs. Multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention. Surgical treatment has been the traditional accepted modality reducing chances of recurrence. Non-surgical treatments with alpha interferon (a-IFN), calcitonin, Denosumab and corticosteroids have been described in literature as adjuvants or as definitive treatments. This case report reviews presentation and currently used therapies for CGCG while describing a uncommon case of central giant cell granuloma occurring in a 45 year old female who presented with a swelling in relation to the left edentulous mandible. Surgical curettage of the lesion along with reconstruction and local delivery of steroid in the cavity was done allowing for the best esthetic and functional result with no recurrence during follow up.

AB - Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. It commonly occurs in anterior mandible with a female prediction in ages below 30yrs. Multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention. Surgical treatment has been the traditional accepted modality reducing chances of recurrence. Non-surgical treatments with alpha interferon (a-IFN), calcitonin, Denosumab and corticosteroids have been described in literature as adjuvants or as definitive treatments. This case report reviews presentation and currently used therapies for CGCG while describing a uncommon case of central giant cell granuloma occurring in a 45 year old female who presented with a swelling in relation to the left edentulous mandible. Surgical curettage of the lesion along with reconstruction and local delivery of steroid in the cavity was done allowing for the best esthetic and functional result with no recurrence during follow up.

UR - http://www.scopus.com/inward/record.url?scp=85053155371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053155371&partnerID=8YFLogxK

U2 - 10.1016/j.omsc.2018.08.001

DO - 10.1016/j.omsc.2018.08.001

M3 - Article

VL - 4

SP - 135

EP - 140

JO - Oral and Maxillofacial Surgery Cases

JF - Oral and Maxillofacial Surgery Cases

SN - 2214-5419

IS - 4

ER -