Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children

What is the Optimal Duration of Antifungal Therapy?

Harsha P. Lashkari, Neil Fernandes, Kishan Alva, Santosh Rai

Research output: Contribution to journalReview article

Abstract

Invasive fungal infections are rare in children with acute lymphoblastic leukemia. It compromises the antileukemia therapy should it happen. Central nervous system fungal infections carry high mortality. We here report the case of a 6.5-year-old girl who developed multiple central nervous system fungal abscesses possibly due to Aspergillus infection during induction therapy for acute lymphoblastic leukemia who has been successfully managed without compromising antileukemia therapy. She has been receiving antifungal therapy and maintenance chemotherapy for 20 months from diagnosis. We reviewed literature about the optimal duration of therapy for such children as the reported cases duration ranged between 4 and 24 months.

Original languageEnglish
Pages (from-to)e312-e317
JournalJournal of Pediatric Hematology/Oncology
Volume39
Issue number6
DOIs
Publication statusPublished - 01-01-2017

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Central Nervous System Fungal Infections
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Maintenance Chemotherapy
Therapeutics
Aspergillus
Abscess
Central Nervous System
Mortality
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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title = "Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children: What is the Optimal Duration of Antifungal Therapy?",
abstract = "Invasive fungal infections are rare in children with acute lymphoblastic leukemia. It compromises the antileukemia therapy should it happen. Central nervous system fungal infections carry high mortality. We here report the case of a 6.5-year-old girl who developed multiple central nervous system fungal abscesses possibly due to Aspergillus infection during induction therapy for acute lymphoblastic leukemia who has been successfully managed without compromising antileukemia therapy. She has been receiving antifungal therapy and maintenance chemotherapy for 20 months from diagnosis. We reviewed literature about the optimal duration of therapy for such children as the reported cases duration ranged between 4 and 24 months.",
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Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children : What is the Optimal Duration of Antifungal Therapy? / Lashkari, Harsha P.; Fernandes, Neil; Alva, Kishan; Rai, Santosh.

In: Journal of Pediatric Hematology/Oncology, Vol. 39, No. 6, 01.01.2017, p. e312-e317.

Research output: Contribution to journalReview article

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