Central neurocytomas: A review of an institutional series of 33 cases

G.R. Menon, A. Patil, M. Abraham, S. Nair

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE:: Neurocytomas (NCs) comprise a rare but distinct clinicopathologic entity, often with a benign course. Our operative series of 33 patients with NCs attempts to review the clinical characteristics of this rare entity. METHOD:: Retrospective analysis of the case records of all the patients with central NCs operated since January 2000. The following prognostic factors were analyzed for statistical significance: age, sex, location, extent of resection, and the histopathologic grade. RESULTS:: The study group included 33 patients with a mean age of 28.87 years (range, 9 to 55 y) and with a male preference (M:F=20:13). Increased intracranial headache was the predominant presenting complaint (27/33; 81.8%), followed by gait imbalance, memory deficits, weakness, and seizures. At the first surgery, gross total removal could be achieved only in 16 cases (48.84%). The majority (26/33; 78.78%) were typical NCs and 7 were atypical NCs. Of the 17 patients with residual lesions, only 4 patients showed an increase in the size of the residue and only 2 of them had symptomatic recurrence requiring repeat surgery. Of the 16 patients who underwent radical excision, 4 had recurrence, 1 requiring repeat surgery. Three of the atypical NCs recurred in spite of gross total resection. We had 5 perioperative mortalities, all related to tumor bleeding and postoperative brain swelling. One child with a recurrent fourth ventricular NC expired after adjuvant chemotherapy. Of the remaining 27 patients, 25 patients had a Glasgow outcome score (GOS) of 5 and 2 were in GOS 3 at the end of a mean follow-up period of 4.63 years (range 2 to 11 y). CONCLUSIONS:: Central NCs are unique tumors of neuronal origin with strong histologic resemblance to other intraventricular tumors of glial origin. NCs are vascular tumors, and their radical removal can be challenging. Although radical surgery is the treatment of choice, they are slow growing, and subtotal resections also provide long-term symptom-free survival even for atypical lesions. Copyright © 2012 by Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalNeurosurgery Quarterly
Volume22
Issue number4
DOIs
Publication statusPublished - 2012

Fingerprint

Neurocytoma
Reoperation
Neoplasms
Recurrence
Brain Edema
Memory Disorders
Adjuvant Chemotherapy
Gait
Neuroglia
Blood Vessels
Headache
Seizures

Cite this

Menon, G.R. ; Patil, A. ; Abraham, M. ; Nair, S. / Central neurocytomas: A review of an institutional series of 33 cases. In: Neurosurgery Quarterly. 2012 ; Vol. 22, No. 4. pp. 213-219.
@article{8e116c12a4ca449abc1eff2a82096a68,
title = "Central neurocytomas: A review of an institutional series of 33 cases",
abstract = "OBJECTIVE:: Neurocytomas (NCs) comprise a rare but distinct clinicopathologic entity, often with a benign course. Our operative series of 33 patients with NCs attempts to review the clinical characteristics of this rare entity. METHOD:: Retrospective analysis of the case records of all the patients with central NCs operated since January 2000. The following prognostic factors were analyzed for statistical significance: age, sex, location, extent of resection, and the histopathologic grade. RESULTS:: The study group included 33 patients with a mean age of 28.87 years (range, 9 to 55 y) and with a male preference (M:F=20:13). Increased intracranial headache was the predominant presenting complaint (27/33; 81.8{\%}), followed by gait imbalance, memory deficits, weakness, and seizures. At the first surgery, gross total removal could be achieved only in 16 cases (48.84{\%}). The majority (26/33; 78.78{\%}) were typical NCs and 7 were atypical NCs. Of the 17 patients with residual lesions, only 4 patients showed an increase in the size of the residue and only 2 of them had symptomatic recurrence requiring repeat surgery. Of the 16 patients who underwent radical excision, 4 had recurrence, 1 requiring repeat surgery. Three of the atypical NCs recurred in spite of gross total resection. We had 5 perioperative mortalities, all related to tumor bleeding and postoperative brain swelling. One child with a recurrent fourth ventricular NC expired after adjuvant chemotherapy. Of the remaining 27 patients, 25 patients had a Glasgow outcome score (GOS) of 5 and 2 were in GOS 3 at the end of a mean follow-up period of 4.63 years (range 2 to 11 y). CONCLUSIONS:: Central NCs are unique tumors of neuronal origin with strong histologic resemblance to other intraventricular tumors of glial origin. NCs are vascular tumors, and their radical removal can be challenging. Although radical surgery is the treatment of choice, they are slow growing, and subtotal resections also provide long-term symptom-free survival even for atypical lesions. Copyright {\circledC} 2012 by Lippincott Williams & Wilkins.",
author = "G.R. Menon and A. Patil and M. Abraham and S. Nair",
note = "cited By 1",
year = "2012",
doi = "10.1097/WNQ.0b013e3182569087",
language = "English",
volume = "22",
pages = "213--219",
journal = "Neurosurgery Quarterly",
issn = "1050-6438",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Central neurocytomas: A review of an institutional series of 33 cases. / Menon, G.R.; Patil, A.; Abraham, M.; Nair, S.

In: Neurosurgery Quarterly, Vol. 22, No. 4, 2012, p. 213-219.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Central neurocytomas: A review of an institutional series of 33 cases

AU - Menon, G.R.

AU - Patil, A.

AU - Abraham, M.

AU - Nair, S.

N1 - cited By 1

PY - 2012

Y1 - 2012

N2 - OBJECTIVE:: Neurocytomas (NCs) comprise a rare but distinct clinicopathologic entity, often with a benign course. Our operative series of 33 patients with NCs attempts to review the clinical characteristics of this rare entity. METHOD:: Retrospective analysis of the case records of all the patients with central NCs operated since January 2000. The following prognostic factors were analyzed for statistical significance: age, sex, location, extent of resection, and the histopathologic grade. RESULTS:: The study group included 33 patients with a mean age of 28.87 years (range, 9 to 55 y) and with a male preference (M:F=20:13). Increased intracranial headache was the predominant presenting complaint (27/33; 81.8%), followed by gait imbalance, memory deficits, weakness, and seizures. At the first surgery, gross total removal could be achieved only in 16 cases (48.84%). The majority (26/33; 78.78%) were typical NCs and 7 were atypical NCs. Of the 17 patients with residual lesions, only 4 patients showed an increase in the size of the residue and only 2 of them had symptomatic recurrence requiring repeat surgery. Of the 16 patients who underwent radical excision, 4 had recurrence, 1 requiring repeat surgery. Three of the atypical NCs recurred in spite of gross total resection. We had 5 perioperative mortalities, all related to tumor bleeding and postoperative brain swelling. One child with a recurrent fourth ventricular NC expired after adjuvant chemotherapy. Of the remaining 27 patients, 25 patients had a Glasgow outcome score (GOS) of 5 and 2 were in GOS 3 at the end of a mean follow-up period of 4.63 years (range 2 to 11 y). CONCLUSIONS:: Central NCs are unique tumors of neuronal origin with strong histologic resemblance to other intraventricular tumors of glial origin. NCs are vascular tumors, and their radical removal can be challenging. Although radical surgery is the treatment of choice, they are slow growing, and subtotal resections also provide long-term symptom-free survival even for atypical lesions. Copyright © 2012 by Lippincott Williams & Wilkins.

AB - OBJECTIVE:: Neurocytomas (NCs) comprise a rare but distinct clinicopathologic entity, often with a benign course. Our operative series of 33 patients with NCs attempts to review the clinical characteristics of this rare entity. METHOD:: Retrospective analysis of the case records of all the patients with central NCs operated since January 2000. The following prognostic factors were analyzed for statistical significance: age, sex, location, extent of resection, and the histopathologic grade. RESULTS:: The study group included 33 patients with a mean age of 28.87 years (range, 9 to 55 y) and with a male preference (M:F=20:13). Increased intracranial headache was the predominant presenting complaint (27/33; 81.8%), followed by gait imbalance, memory deficits, weakness, and seizures. At the first surgery, gross total removal could be achieved only in 16 cases (48.84%). The majority (26/33; 78.78%) were typical NCs and 7 were atypical NCs. Of the 17 patients with residual lesions, only 4 patients showed an increase in the size of the residue and only 2 of them had symptomatic recurrence requiring repeat surgery. Of the 16 patients who underwent radical excision, 4 had recurrence, 1 requiring repeat surgery. Three of the atypical NCs recurred in spite of gross total resection. We had 5 perioperative mortalities, all related to tumor bleeding and postoperative brain swelling. One child with a recurrent fourth ventricular NC expired after adjuvant chemotherapy. Of the remaining 27 patients, 25 patients had a Glasgow outcome score (GOS) of 5 and 2 were in GOS 3 at the end of a mean follow-up period of 4.63 years (range 2 to 11 y). CONCLUSIONS:: Central NCs are unique tumors of neuronal origin with strong histologic resemblance to other intraventricular tumors of glial origin. NCs are vascular tumors, and their radical removal can be challenging. Although radical surgery is the treatment of choice, they are slow growing, and subtotal resections also provide long-term symptom-free survival even for atypical lesions. Copyright © 2012 by Lippincott Williams & Wilkins.

U2 - 10.1097/WNQ.0b013e3182569087

DO - 10.1097/WNQ.0b013e3182569087

M3 - Article

VL - 22

SP - 213

EP - 219

JO - Neurosurgery Quarterly

JF - Neurosurgery Quarterly

SN - 1050-6438

IS - 4

ER -