Abstract

Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic infections and tumours. It was recognized early in the HIV epidemic, that the diagnosis of the focal CNS lesions would be difficult. A 21-year old female, known case of a retroviral disease, presented to our institute with complaints of fever, headache and vomiting. A computed tomography scan of her brain showed a single ring enhancing lesion in the left basal ganglia. Toxoplasma serology revealed raised IgG antibody levels. Based on the CT features and the positive toxoplasma serology, a diagnosis of cerebral toxoplasmosis was made. She was treated with trimethoprim/sulfamethoxazole and pyrimethamine/ sulfadoxine. The patient was symptomatically better after 72 hours. After 21 days, a repeat CT of brain was done, which showed significant resolution of the lesions. Cerebral toxoplasmosis is still the commonest cerebral opportunistic infection in HIV-infected patients.

Original languageEnglish
Pages (from-to)1083-1085
Number of pages3
JournalJournal of Clinical and Diagnostic Research
Volume6
Issue number6
DOIs
Publication statusPublished - 10-08-2012

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Intracranial Tuberculoma
Cerebral Toxoplasmosis
Brain
Opportunistic Infections
Toxoplasma
Serology
Sulfamethoxazole Drug Combination Trimethoprim
HIV
Tomography
Tumors
Immunoglobulin G
Basal Ganglia
Vomiting
Headache
Antibodies
Acquired Immunodeficiency Syndrome
Fever
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Clinical Biochemistry

Cite this

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title = "Cerebral toxoplasmosis mimicking intracranial tuberculoma",
abstract = "Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic infections and tumours. It was recognized early in the HIV epidemic, that the diagnosis of the focal CNS lesions would be difficult. A 21-year old female, known case of a retroviral disease, presented to our institute with complaints of fever, headache and vomiting. A computed tomography scan of her brain showed a single ring enhancing lesion in the left basal ganglia. Toxoplasma serology revealed raised IgG antibody levels. Based on the CT features and the positive toxoplasma serology, a diagnosis of cerebral toxoplasmosis was made. She was treated with trimethoprim/sulfamethoxazole and pyrimethamine/ sulfadoxine. The patient was symptomatically better after 72 hours. After 21 days, a repeat CT of brain was done, which showed significant resolution of the lesions. Cerebral toxoplasmosis is still the commonest cerebral opportunistic infection in HIV-infected patients.",
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Cerebral toxoplasmosis mimicking intracranial tuberculoma. / Madi, Deepak; Achappa, Basavaprabhu; Rao, Satish; Adhikari, Prabha; Mahalingam, Soundarya.

In: Journal of Clinical and Diagnostic Research, Vol. 6, No. 6, 10.08.2012, p. 1083-1085.

Research output: Contribution to journalArticle

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AU - Achappa, Basavaprabhu

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AB - Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic infections and tumours. It was recognized early in the HIV epidemic, that the diagnosis of the focal CNS lesions would be difficult. A 21-year old female, known case of a retroviral disease, presented to our institute with complaints of fever, headache and vomiting. A computed tomography scan of her brain showed a single ring enhancing lesion in the left basal ganglia. Toxoplasma serology revealed raised IgG antibody levels. Based on the CT features and the positive toxoplasma serology, a diagnosis of cerebral toxoplasmosis was made. She was treated with trimethoprim/sulfamethoxazole and pyrimethamine/ sulfadoxine. The patient was symptomatically better after 72 hours. After 21 days, a repeat CT of brain was done, which showed significant resolution of the lesions. Cerebral toxoplasmosis is still the commonest cerebral opportunistic infection in HIV-infected patients.

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