Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India

Suchitra Thunga, Anusmitha Andrews, John Ramapuram, Kapaettu Satyamoorthy, Hema Kini, B. Unnikrishnan, Prabha Adhikari, Prakhar Singh, Shama Prasada Kabekkodu, Samatha Bhat, Anagha Kadam, Avinash K. Shetty

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). Conclusion: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.

Original languageEnglish
Pages (from-to)1822-1828
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume42
Issue number12
DOIs
Publication statusPublished - 01-12-2016

Fingerprint

Papillomaviridae
Virus Diseases
India
HIV
Cervical Intraepithelial Neoplasia
Papanicolaou Test
CD4 Lymphocyte Count
Opportunistic Infections
Uterine Cervical Neoplasms
Cell Biology

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

@article{7b1ee87e6df9433c82b21f0e91ec9c24,
title = "Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India",
abstract = "Aim: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results: The overall prevalence of HPV infection was 57.7{\%}. HPV 16 was the commonest genotype found (38.5{\%}); HPV 16 and 18 put together contributed to 73.3{\%} of HPV infection; 27.5{\%} of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12{\%}) and in those without opportunistic infections (17.8{\%}). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7{\%}) as compared to women with normal cytology (52.1{\%}). Conclusion: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.",
author = "Suchitra Thunga and Anusmitha Andrews and John Ramapuram and Kapaettu Satyamoorthy and Hema Kini and B. Unnikrishnan and Prabha Adhikari and Prakhar Singh and Kabekkodu, {Shama Prasada} and Samatha Bhat and Anagha Kadam and Shetty, {Avinash K.}",
year = "2016",
month = "12",
day = "1",
doi = "10.1111/jog.13111",
language = "English",
volume = "42",
pages = "1822--1828",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "12",

}

Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India. / Thunga, Suchitra; Andrews, Anusmitha; Ramapuram, John; Satyamoorthy, Kapaettu; Kini, Hema; Unnikrishnan, B.; Adhikari, Prabha; Singh, Prakhar; Kabekkodu, Shama Prasada; Bhat, Samatha; Kadam, Anagha; Shetty, Avinash K.

In: Journal of Obstetrics and Gynaecology Research, Vol. 42, No. 12, 01.12.2016, p. 1822-1828.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India

AU - Thunga, Suchitra

AU - Andrews, Anusmitha

AU - Ramapuram, John

AU - Satyamoorthy, Kapaettu

AU - Kini, Hema

AU - Unnikrishnan, B.

AU - Adhikari, Prabha

AU - Singh, Prakhar

AU - Kabekkodu, Shama Prasada

AU - Bhat, Samatha

AU - Kadam, Anagha

AU - Shetty, Avinash K.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Aim: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). Conclusion: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.

AB - Aim: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). Conclusion: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.

UR - http://www.scopus.com/inward/record.url?scp=85002648997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85002648997&partnerID=8YFLogxK

U2 - 10.1111/jog.13111

DO - 10.1111/jog.13111

M3 - Article

VL - 42

SP - 1822

EP - 1828

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

IS - 12

ER -