Changes in glycated proteins during impaired glucose tolerance

Pragna Rao, Anuradha Kumar, N. R. Rau, T. N. Pattabiraman

Research output: Contribution to journalArticle

Abstract

In persons with impaired glucose tolerance, serum glycated proteins (9.44±1.46μg hexose/mg protein) increased 1.69-fold (P<0.001) over control subjects compared to an increase of 1.95-fold in overt diabetics. However, correlations between serum glycated protein values and 2 h blood sugar values during the tolerance test (r=0.39) and between the former and graph area (r=0.30) were not strong. Glycated albumin (2.25 mol hexose/mol protein) and glycated haemoglobin (0.398±0.07 mol hexose/mol protein) in the study group also showed 1.67 and 1.24-fold increase respectively compared to controls. Fairly good correlations between glycated serum protein and glycated albumin (r=0.50) and glycated haemoglobin (r=0.45) were observed during this study. The data suggest that measurement of glycated proteins will be a useful index to detect impaired glucose tolerance.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalIndian Journal of Clinical Biochemistry
Volume5
Issue number2
DOIs
Publication statusPublished - 07-1990

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All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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