Changing trends of lower respiratory tract pathogens

A Five year Study

A. Shenoy Padmaja, K. Purandare Mrudghandha, Chawla Kiran

Research output: Contribution to journalArticle

Abstract

Context: Lower respiratory tract infections (LRTIs) are one of the most common problems encountered by physicians posing huge impact on health care system. Among the diverse respiratory bacterial etiological agents, Gram-negative bacilli predominate in developing countries. Antimicrobial resistance among the respiratory pathogens is a raising concern leading to prolonged hospital stay and high morbidity/mortality. Aims: The aim of the study was to determine the common bacterial aetiological agents causing LRTIs and to study their changing trends of antibiotic resistance pattern. Settings and design: Retrospective study was conducted from January 2012 to December 2016 in Department of Microbiology, tertiary care teaching hospital, Manipal. Methods and materials: Respiratory specimens including Broncho alveolar Lavage (BAL), Endotracheal (ET) aspirate and sputum samples were processed for Gram stain and culture. The respiratory pathogens were identified and were subjected to antibiotic susceptibility testing following standard techniques. Statistical analysis used: Obtained results were analysed by SPSS version 16. Changing trends of antibiotic resistance was studied by linear regression. Results: Of the 22095 samples received, significant bacterial growth was observed in 6766 (30.6%) specimens. Gram-negatives (5581, 82.5%) outnumbered the Gram- positive isolates (1156, 17%). Among the Gram-negative bacilli (5581, 82.5%), non-fermenters were (3297, 59%) predominantly isolated followed by members of Enterobacteriaceae (1622, 29%). Among the non-fermenters, Acinetobacter baumannii was the frequent isolate (1696, 51.4%) showing significant increasing trends of resistance to cefoperazone-sulbactam (R2= 0.85 and P value 0.03) and maximum increase in antibiotic resistance was observed in the year 2016 (77%). Conclusion: Significant upsurge in the resistance trends of common antibiotics in LRTIs calls for judicious usage of antibiotics & strict infection control practices.

Original languageEnglish
JournalAnnals of Tropical Medicine and Public Health
Volume19
Issue numberSpecial Issue
Publication statusPublished - 01-05-2019

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Microbial Drug Resistance
Respiratory Tract Infections
Respiratory System
Anti-Bacterial Agents
Bacillus
Cefoperazone
Sulbactam
Acinetobacter baumannii
Therapeutic Irrigation
Enterobacteriaceae
Tertiary Healthcare
Infection Control
Microbiology
Sputum
Teaching Hospitals
Developing Countries
Linear Models
Length of Stay
Retrospective Studies
Morbidity

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Shenoy Padmaja, A. ; Purandare Mrudghandha, K. ; Kiran, Chawla. / Changing trends of lower respiratory tract pathogens : A Five year Study. In: Annals of Tropical Medicine and Public Health. 2019 ; Vol. 19, No. Special Issue.
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title = "Changing trends of lower respiratory tract pathogens: A Five year Study",
abstract = "Context: Lower respiratory tract infections (LRTIs) are one of the most common problems encountered by physicians posing huge impact on health care system. Among the diverse respiratory bacterial etiological agents, Gram-negative bacilli predominate in developing countries. Antimicrobial resistance among the respiratory pathogens is a raising concern leading to prolonged hospital stay and high morbidity/mortality. Aims: The aim of the study was to determine the common bacterial aetiological agents causing LRTIs and to study their changing trends of antibiotic resistance pattern. Settings and design: Retrospective study was conducted from January 2012 to December 2016 in Department of Microbiology, tertiary care teaching hospital, Manipal. Methods and materials: Respiratory specimens including Broncho alveolar Lavage (BAL), Endotracheal (ET) aspirate and sputum samples were processed for Gram stain and culture. The respiratory pathogens were identified and were subjected to antibiotic susceptibility testing following standard techniques. Statistical analysis used: Obtained results were analysed by SPSS version 16. Changing trends of antibiotic resistance was studied by linear regression. Results: Of the 22095 samples received, significant bacterial growth was observed in 6766 (30.6{\%}) specimens. Gram-negatives (5581, 82.5{\%}) outnumbered the Gram- positive isolates (1156, 17{\%}). Among the Gram-negative bacilli (5581, 82.5{\%}), non-fermenters were (3297, 59{\%}) predominantly isolated followed by members of Enterobacteriaceae (1622, 29{\%}). Among the non-fermenters, Acinetobacter baumannii was the frequent isolate (1696, 51.4{\%}) showing significant increasing trends of resistance to cefoperazone-sulbactam (R2= 0.85 and P value 0.03) and maximum increase in antibiotic resistance was observed in the year 2016 (77{\%}). Conclusion: Significant upsurge in the resistance trends of common antibiotics in LRTIs calls for judicious usage of antibiotics & strict infection control practices.",
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Changing trends of lower respiratory tract pathogens : A Five year Study. / Shenoy Padmaja, A.; Purandare Mrudghandha, K.; Kiran, Chawla.

In: Annals of Tropical Medicine and Public Health, Vol. 19, No. Special Issue, 01.05.2019.

Research output: Contribution to journalArticle

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T2 - A Five year Study

AU - Shenoy Padmaja, A.

AU - Purandare Mrudghandha, K.

AU - Kiran, Chawla

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AB - Context: Lower respiratory tract infections (LRTIs) are one of the most common problems encountered by physicians posing huge impact on health care system. Among the diverse respiratory bacterial etiological agents, Gram-negative bacilli predominate in developing countries. Antimicrobial resistance among the respiratory pathogens is a raising concern leading to prolonged hospital stay and high morbidity/mortality. Aims: The aim of the study was to determine the common bacterial aetiological agents causing LRTIs and to study their changing trends of antibiotic resistance pattern. Settings and design: Retrospective study was conducted from January 2012 to December 2016 in Department of Microbiology, tertiary care teaching hospital, Manipal. Methods and materials: Respiratory specimens including Broncho alveolar Lavage (BAL), Endotracheal (ET) aspirate and sputum samples were processed for Gram stain and culture. The respiratory pathogens were identified and were subjected to antibiotic susceptibility testing following standard techniques. Statistical analysis used: Obtained results were analysed by SPSS version 16. Changing trends of antibiotic resistance was studied by linear regression. Results: Of the 22095 samples received, significant bacterial growth was observed in 6766 (30.6%) specimens. Gram-negatives (5581, 82.5%) outnumbered the Gram- positive isolates (1156, 17%). Among the Gram-negative bacilli (5581, 82.5%), non-fermenters were (3297, 59%) predominantly isolated followed by members of Enterobacteriaceae (1622, 29%). Among the non-fermenters, Acinetobacter baumannii was the frequent isolate (1696, 51.4%) showing significant increasing trends of resistance to cefoperazone-sulbactam (R2= 0.85 and P value 0.03) and maximum increase in antibiotic resistance was observed in the year 2016 (77%). Conclusion: Significant upsurge in the resistance trends of common antibiotics in LRTIs calls for judicious usage of antibiotics & strict infection control practices.

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