TY - GEN
T1 - Characterization, composition, and biological properties of extracellular vesicles generated from human induced pluripotent stem cell-derived neural stem cells
AU - Upadhya, Raghavendra
AU - Madhu, Leelavathi N.
AU - Attaluri, Sahithi
AU - Gitai, Daniel
AU - Pinson, Marisa R.
AU - Kodali, Maheedhar
AU - Shetty, Geetha A.
AU - Zanirati, Gabriele
AU - Kumar, Smrithi
AU - Shuai, Bing
AU - Weintraub, Susan T.
AU - Shetty, Ashok K.
PY - 2020
Y1 - 2020
N2 - Neural stem cell (NSC) therapy has shown promise for brain repair after injury or disease mostly through bystander effects. Nevertheless, the translation of NSCs derived from human induced pluripotent stem cells (hiPSCs) to the clinic remain constrained due to safety issues, which include immunogenic risks, tumorigenesis potential, and incomplete differentiation. A way to avoid these issues is by using extracellular vesicles (EVs) generated from NSCs, as NSC-EVs likely have similar neuroprotective properties as NSCs and are amenable for non-invasive administration as an autologous or allogeneic off-the-shelf product. However, this would require reliable purification and characterization processes, and testing of EVs for composition and biological properties.
AB - Neural stem cell (NSC) therapy has shown promise for brain repair after injury or disease mostly through bystander effects. Nevertheless, the translation of NSCs derived from human induced pluripotent stem cells (hiPSCs) to the clinic remain constrained due to safety issues, which include immunogenic risks, tumorigenesis potential, and incomplete differentiation. A way to avoid these issues is by using extracellular vesicles (EVs) generated from NSCs, as NSC-EVs likely have similar neuroprotective properties as NSCs and are amenable for non-invasive administration as an autologous or allogeneic off-the-shelf product. However, this would require reliable purification and characterization processes, and testing of EVs for composition and biological properties.
M3 - Conference contribution
T3 - ANNUAL MEETING ISEV 2020
BT - Characterization, composition, and biological properties of extracellular vesicles generated from human induced pluripotent stem cell-derived neural stem cells
PB - International Society for Extracellular Vesicles
CY - Philadalphia, USA.
ER -
