Characterization, composition, and biological properties of extracellular vesicles generated from human induced pluripotent stem cell-derived neural stem cells

Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Daniel Gitai, Marisa R. Pinson, Maheedhar Kodali, Geetha A. Shetty, Gabriele Zanirati, Smrithi Kumar, Bing Shuai, Susan T. Weintraub, Ashok K. Shetty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neural stem cell (NSC) therapy has shown promise for brain repair after injury or disease mostly through bystander effects. Nevertheless, the translation of NSCs derived from human induced pluripotent stem cells (hiPSCs) to the clinic remain constrained due to safety issues, which include immunogenic risks, tumorigenesis potential, and incomplete differentiation. A way to avoid these issues is by using extracellular vesicles (EVs) generated from NSCs, as NSC-EVs likely have similar neuroprotective properties as NSCs and are amenable for non-invasive administration as an autologous or allogeneic off-the-shelf product. However, this would require reliable purification and characterization processes, and testing of EVs for composition and biological properties.
Original languageEnglish
Title of host publicationCharacterization, composition, and biological properties of extracellular vesicles generated from human induced pluripotent stem cell-derived neural stem cells
Place of PublicationPhiladalphia, USA.
PublisherInternational Society for Extracellular Vesicles
Publication statusPublished - 2020

Publication series

NameANNUAL MEETING ISEV 2020

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