Characterization of Plasmodium vivax pvmdr1 Polymorphisms in Isolates from Mangaluru, India

Costanza Tacoli, Prabhanjan P. Gai, Konrad Siegert, Jakob Wedam, Suyamindra S. Kulkarni, Rashmi Rasalkar, Archith Boloor, Animesh Jain, Chakrapani Mahabala, Shantaram Baliga, Damodara Shenoy, Pramod Gai, Rajeshwari Devi, Frank P. Mockenhaupt

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Abstract

India accounts for approximately half of the global Plasmodium vivax cases, but information as to the presence of chloroquine (CQ) resistance is scarce. In an observational study in Mangaluru, south-western India, of 116 vivax malaria patients analyzed, 89.5% (102/114) had cleared parasitemia on days two or three of CQ treatment. Two remaining patients presented on days four and five without parasitemia. One hundred eight isolates of these 116 patients were successfully sequenced for pvmdr1 polymorphisms. Eight non-synonymous polymorphisms but no wild-type isolate were detected. Ten pvmdr1 haplotypes were observed with mutations T958M and F1076L occurring in all isolates, whereas the candidate CQ resistance marker Y976F was present in one isolate only. Pvmdr1 polymorphisms were not associated with early parasite clearance. The high proportion of early parasite clearance and the virtual absence of pvmdr1 Y976F and of sextuple pvmdr1 mutants suggest that CQ in the study area is still sufficiently effective. However, the abundance of pvmdr1 mutations in the local parasite population warrants monitoring.

Original languageEnglish
Pages (from-to)416-417
Number of pages2
JournalThe American journal of tropical medicine and hygiene
Volume101
Issue number2
DOIs
Publication statusPublished - 01-08-2019

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All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Tacoli, C., Gai, P. P., Siegert, K., Wedam, J., Kulkarni, S. S., Rasalkar, R., Boloor, A., Jain, A., Mahabala, C., Baliga, S., Shenoy, D., Gai, P., Devi, R., & Mockenhaupt, F. P. (2019). Characterization of Plasmodium vivax pvmdr1 Polymorphisms in Isolates from Mangaluru, India. The American journal of tropical medicine and hygiene, 101(2), 416-417. https://doi.org/10.4269/ajtmh.19-0224