Chelating agents and antioxidants: Pragmatic approaches for management of Buerger's disease

M. Sonal Sekhar, M. K. Unnikrishnan, Gabriel Sunil Rodrigues, Navya Vyas

Research output: Contribution to journalReview article

Abstract

Buerger's disease (BD) is a peripheral vascular disease, the etiology of which was largely unknown until recently. Currently, various studies demonstrated the involvement of heavy metals in tobacco and other source as one of the causative factors. Heavy metals induce vascular dysfunction by inducing high oxidative stress, reducing the activities of endothelial nitric oxide synthase and enhancing the phosphorylation of myosin light chain kinases. Targeting and modulating these pathological mechanisms may provide novel pharmacological intervention to halt the progression of the BD. Hence, we hypothesized that chelating agents and antioxidants alone or combination therapy can help manage BD.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalReviews in Vascular Medicine
Volume4-5
DOIs
Publication statusPublished - 01-05-2016

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Thromboangiitis Obliterans
Chelating Agents
Antioxidants
Heavy Metals
Myosin-Light-Chain Kinase
Peripheral Vascular Diseases
Nitric Oxide Synthase Type III
Tobacco
Blood Vessels
Oxidative Stress
Phosphorylation
Pharmacology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Chelating agents and antioxidants: Pragmatic approaches for management of Buerger's disease",
abstract = "Buerger's disease (BD) is a peripheral vascular disease, the etiology of which was largely unknown until recently. Currently, various studies demonstrated the involvement of heavy metals in tobacco and other source as one of the causative factors. Heavy metals induce vascular dysfunction by inducing high oxidative stress, reducing the activities of endothelial nitric oxide synthase and enhancing the phosphorylation of myosin light chain kinases. Targeting and modulating these pathological mechanisms may provide novel pharmacological intervention to halt the progression of the BD. Hence, we hypothesized that chelating agents and antioxidants alone or combination therapy can help manage BD.",
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Chelating agents and antioxidants : Pragmatic approaches for management of Buerger's disease. / Sekhar, M. Sonal; Unnikrishnan, M. K.; Rodrigues, Gabriel Sunil; Vyas, Navya.

In: Reviews in Vascular Medicine, Vol. 4-5, 01.05.2016, p. 23-25.

Research output: Contribution to journalReview article

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T1 - Chelating agents and antioxidants

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AU - Sekhar, M. Sonal

AU - Unnikrishnan, M. K.

AU - Rodrigues, Gabriel Sunil

AU - Vyas, Navya

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AB - Buerger's disease (BD) is a peripheral vascular disease, the etiology of which was largely unknown until recently. Currently, various studies demonstrated the involvement of heavy metals in tobacco and other source as one of the causative factors. Heavy metals induce vascular dysfunction by inducing high oxidative stress, reducing the activities of endothelial nitric oxide synthase and enhancing the phosphorylation of myosin light chain kinases. Targeting and modulating these pathological mechanisms may provide novel pharmacological intervention to halt the progression of the BD. Hence, we hypothesized that chelating agents and antioxidants alone or combination therapy can help manage BD.

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