Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

G. B.S. Reddy, A. B. Melkhani, G. A. Kalyani, J. Venkata Rao, Annie Shirwaikar, Mohan Kotian, Rama Ramani, K. S. Aithal, A. L. Udupa, Gopalakrishna Bhat, K. K. Srinivasan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalPharmaceutical Biology
Volume29
Issue number2
DOIs
Publication statusPublished - 1991

Fingerprint

Oils
Pharmacology
Thymol
Griseofulvin
Anthelmintics
Ethylene Glycol
Volatile Oils
Complex Mixtures
Anti-Inflammatory Agents
Inflammation
Wounds and Injuries
hymenoxin
nevadensin

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Reddy, G. B. S., Melkhani, A. B., Kalyani, G. A., Rao, J. V., Shirwaikar, A., Kotian, M., ... Srinivasan, K. K. (1991). Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla. Pharmaceutical Biology, 29(2), 145-153. https://doi.org/10.3109/13880209109082868
Reddy, G. B.S. ; Melkhani, A. B. ; Kalyani, G. A. ; Rao, J. Venkata ; Shirwaikar, Annie ; Kotian, Mohan ; Ramani, Rama ; Aithal, K. S. ; Udupa, A. L. ; Bhat, Gopalakrishna ; Srinivasan, K. K. / Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla. In: Pharmaceutical Biology. 1991 ; Vol. 29, No. 2. pp. 145-153.
@article{bcd196317f7d4df691193c2e38db8d85,
title = "Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla",
abstract = "Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2{\%} and thymol (38.2{\%} The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.",
author = "Reddy, {G. B.S.} and Melkhani, {A. B.} and Kalyani, {G. A.} and Rao, {J. Venkata} and Annie Shirwaikar and Mohan Kotian and Rama Ramani and Aithal, {K. S.} and Udupa, {A. L.} and Gopalakrishna Bhat and Srinivasan, {K. K.}",
year = "1991",
doi = "10.3109/13880209109082868",
language = "English",
volume = "29",
pages = "145--153",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "2",

}

Reddy, GBS, Melkhani, AB, Kalyani, GA, Rao, JV, Shirwaikar, A, Kotian, M, Ramani, R, Aithal, KS, Udupa, AL, Bhat, G & Srinivasan, KK 1991, 'Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla', Pharmaceutical Biology, vol. 29, no. 2, pp. 145-153. https://doi.org/10.3109/13880209109082868

Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla. / Reddy, G. B.S.; Melkhani, A. B.; Kalyani, G. A.; Rao, J. Venkata; Shirwaikar, Annie; Kotian, Mohan; Ramani, Rama; Aithal, K. S.; Udupa, A. L.; Bhat, Gopalakrishna; Srinivasan, K. K.

In: Pharmaceutical Biology, Vol. 29, No. 2, 1991, p. 145-153.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

AU - Reddy, G. B.S.

AU - Melkhani, A. B.

AU - Kalyani, G. A.

AU - Rao, J. Venkata

AU - Shirwaikar, Annie

AU - Kotian, Mohan

AU - Ramani, Rama

AU - Aithal, K. S.

AU - Udupa, A. L.

AU - Bhat, Gopalakrishna

AU - Srinivasan, K. K.

PY - 1991

Y1 - 1991

N2 - Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

AB - Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

UR - http://www.scopus.com/inward/record.url?scp=79951825821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951825821&partnerID=8YFLogxK

U2 - 10.3109/13880209109082868

DO - 10.3109/13880209109082868

M3 - Article

VL - 29

SP - 145

EP - 153

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 2

ER -