Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

G. B.S. Reddy, A. B. Melkhani, G. A. Kalyani, J. Venkata Rao, Annie Shirwaikar, Mohan Kotian, Rama Ramani, K. S. Aithal, A. L. Udupa, Gopalakrishna Bhat, K. K. Srinivasan

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Abstract

Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalPharmaceutical Biology
Volume29
Issue number2
DOIs
Publication statusPublished - 1991

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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    Reddy, G. B. S., Melkhani, A. B., Kalyani, G. A., Rao, J. V., Shirwaikar, A., Kotian, M., Ramani, R., Aithal, K. S., Udupa, A. L., Bhat, G., & Srinivasan, K. K. (1991). Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla. Pharmaceutical Biology, 29(2), 145-153. https://doi.org/10.3109/13880209109082868