Chemical investigation and antihepatotoxic activity of the fruits of Lagenaria siceraria

A. Shirwaikar, K.K. Sreenivasan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The antihepatotoxic activity of different fractions of the ethanolic extract of Lagenaria siceraria fruit, administered orally to different groups of rats was evaluated using the CCl4-induced hepatotoxicity test. All fractions tested, in a dose of 250 mg/kg showed significant activity, with the petroleum ether traction exhibiting comparatively higher activity. Two steroids were isolated from the petroleum ether fraction and they were identified as fucosterol and campesterol.
Original languageUndefined/Unknown
Pages (from-to)197-202
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume58
Issue number5
Publication statusPublished - 1996

Cite this

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abstract = "The antihepatotoxic activity of different fractions of the ethanolic extract of Lagenaria siceraria fruit, administered orally to different groups of rats was evaluated using the CCl4-induced hepatotoxicity test. All fractions tested, in a dose of 250 mg/kg showed significant activity, with the petroleum ether traction exhibiting comparatively higher activity. Two steroids were isolated from the petroleum ether fraction and they were identified as fucosterol and campesterol.",
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Chemical investigation and antihepatotoxic activity of the fruits of Lagenaria siceraria. / Shirwaikar, A.; Sreenivasan, K.K.

In: Indian Journal of Pharmaceutical Sciences, Vol. 58, No. 5, 1996, p. 197-202.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Shirwaikar, A.

AU - Sreenivasan, K.K.

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AB - The antihepatotoxic activity of different fractions of the ethanolic extract of Lagenaria siceraria fruit, administered orally to different groups of rats was evaluated using the CCl4-induced hepatotoxicity test. All fractions tested, in a dose of 250 mg/kg showed significant activity, with the petroleum ether traction exhibiting comparatively higher activity. Two steroids were isolated from the petroleum ether fraction and they were identified as fucosterol and campesterol.

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