Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus

K.R. Prabhakar, K.K. Srinivasan, P.G.M. Rao

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A systematic chemical investigation of Coronopus didymus was undertaken. A new flavone glycoside, viz., chrysoeriol-(6″-OAc)-4′-β-D-glucoside, along with free chrysoeriol and stigmastanol, were isolated and characterized on the basis of chemical and spectral studies. The ethanol and aqueous extracts of the whole plant were subjected to anti-inflammatory and wound healing activity studies. Both ethanol and aqueous extracts showed statistically significant wound healing activity, whereas only the aqueous extract showed significant anti-inflammatory activity.
Original languageEnglish
Pages (from-to)490-493
Number of pages4
JournalPharmaceutical Biology
Volume40
Issue number7
DOIs
Publication statusPublished - 2002
Externally publishedYes

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flavone
Wound Healing
Anti-Inflammatory Agents
Ethanol
Plant Extracts
Glucosides
Glycosides
chrysoeriol
stigmastanol

Cite this

Prabhakar, K.R. ; Srinivasan, K.K. ; Rao, P.G.M. / Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus. In: Pharmaceutical Biology. 2002 ; Vol. 40, No. 7. pp. 490-493.
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abstract = "A systematic chemical investigation of Coronopus didymus was undertaken. A new flavone glycoside, viz., chrysoeriol-(6″-OAc)-4′-β-D-glucoside, along with free chrysoeriol and stigmastanol, were isolated and characterized on the basis of chemical and spectral studies. The ethanol and aqueous extracts of the whole plant were subjected to anti-inflammatory and wound healing activity studies. Both ethanol and aqueous extracts showed statistically significant wound healing activity, whereas only the aqueous extract showed significant anti-inflammatory activity.",
author = "K.R. Prabhakar and K.K. Srinivasan and P.G.M. Rao",
note = "Cited By :18 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Srinivasan, K.K.; Dept. of Pharmaceutical Chemistry, College of Pharmaceutics Sciences, Manipal-576119, Karnataka, India; email: pansrini@yahoo.co.in Chemicals/CAS: alcohol, 64-17-5; benzyl isothiocyanate, 622-78-6; chrysoeriol, 491-71-4; sitostanol, 19044-02-1, 83-45-4 References: Budzikiewicz, H., Djerassi, C., Mass spectrometry in structural and stereochemical problems. I. Steroid ketones (1962) J Am Chem Soc, 84, pp. 1169-1182; De Ruiz, R.E.L., Fusco, M., Sosa, A., Ruiz, S.O., Constituents of Coronopus didymus (1994) Fitoterpia, 65, pp. 181-182; Ehrlich, H.P., Hunt, T.K., Effects of cortisone and vitamin A on wound healing (1969) Ann Surg, 170, pp. 203-206; Evans, W.C., (1989) Treas and Evan's Pharmacognosy, pp. 247-302. , London, Bailliere Tindall-Carell and Collier Mac Millan; Heleming, H., Wound healing and seratonin antagonist (1969) Abstact Surg Gynecol Obstet, 129, pp. 673-675; Composition of essential oil of coronopus didymus seeds (1989) J Chem Soc of Pakistan, 11, pp. 80-81. , Inam ul haque; Khan, M.S.Y., Javed, K., Khan, M.H., Chemical investigation of Coronopus didymus (Jungli hall or Panacholi) (1990) Indian J Nat Prod, 6 (2), pp. 18-20; Lee, K.H., Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin (1968) J Pharm Sci, 57, pp. 1042-1043; Madan, B.R., Khanna, N.K., Effect of creatinine on various experimentally induced inflammatory models (1979) Indian J Physiol Pharmacol, 17, pp. 191-192; Markham, K.R., (1982) Techniques of Flavonoid Identification, pp. 1-94. , Biological Techniques Series, eds., London, Academic Press; Markham, K.R., Mohan Chari, V., (1975) The Flavonoids: Advances in Research, pp. 19-131. , Harborne JB, Mabry TJ, eds., London, Chapman & Hall; McDowall, F.H., Mortan, I.D., McDowell, A.K.R., Land-cress taint in cream and butter (1947) New Zealand J Sci Technol, A28, pp. 305-307; Patil, P.A., Kulkarni, D.R., Effect of anti-proliferative agents on healing of incision wounds in rats (1985) Ind J Exp Biol, 23, pp. 149-150; Vogel, A.I., Infrared Nuclear magnetic resonance and mass spectrometry correlation tables (1991) Vogel's Text Book of Practical Organic Chemistry, 5th Ed, pp. 1412-1441. , Furniss BS, Hannaford AJ, Smith PWG, Tatchell AR, eds., London, ELBS",
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Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus. / Prabhakar, K.R.; Srinivasan, K.K.; Rao, P.G.M.

In: Pharmaceutical Biology, Vol. 40, No. 7, 2002, p. 490-493.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus

AU - Prabhakar, K.R.

AU - Srinivasan, K.K.

AU - Rao, P.G.M.

N1 - Cited By :18 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Srinivasan, K.K.; Dept. of Pharmaceutical Chemistry, College of Pharmaceutics Sciences, Manipal-576119, Karnataka, India; email: pansrini@yahoo.co.in Chemicals/CAS: alcohol, 64-17-5; benzyl isothiocyanate, 622-78-6; chrysoeriol, 491-71-4; sitostanol, 19044-02-1, 83-45-4 References: Budzikiewicz, H., Djerassi, C., Mass spectrometry in structural and stereochemical problems. I. Steroid ketones (1962) J Am Chem Soc, 84, pp. 1169-1182; De Ruiz, R.E.L., Fusco, M., Sosa, A., Ruiz, S.O., Constituents of Coronopus didymus (1994) Fitoterpia, 65, pp. 181-182; Ehrlich, H.P., Hunt, T.K., Effects of cortisone and vitamin A on wound healing (1969) Ann Surg, 170, pp. 203-206; Evans, W.C., (1989) Treas and Evan's Pharmacognosy, pp. 247-302. , London, Bailliere Tindall-Carell and Collier Mac Millan; Heleming, H., Wound healing and seratonin antagonist (1969) Abstact Surg Gynecol Obstet, 129, pp. 673-675; Composition of essential oil of coronopus didymus seeds (1989) J Chem Soc of Pakistan, 11, pp. 80-81. , Inam ul haque; Khan, M.S.Y., Javed, K., Khan, M.H., Chemical investigation of Coronopus didymus (Jungli hall or Panacholi) (1990) Indian J Nat Prod, 6 (2), pp. 18-20; Lee, K.H., Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin (1968) J Pharm Sci, 57, pp. 1042-1043; Madan, B.R., Khanna, N.K., Effect of creatinine on various experimentally induced inflammatory models (1979) Indian J Physiol Pharmacol, 17, pp. 191-192; Markham, K.R., (1982) Techniques of Flavonoid Identification, pp. 1-94. , Biological Techniques Series, eds., London, Academic Press; Markham, K.R., Mohan Chari, V., (1975) The Flavonoids: Advances in Research, pp. 19-131. , Harborne JB, Mabry TJ, eds., London, Chapman & Hall; McDowall, F.H., Mortan, I.D., McDowell, A.K.R., Land-cress taint in cream and butter (1947) New Zealand J Sci Technol, A28, pp. 305-307; Patil, P.A., Kulkarni, D.R., Effect of anti-proliferative agents on healing of incision wounds in rats (1985) Ind J Exp Biol, 23, pp. 149-150; Vogel, A.I., Infrared Nuclear magnetic resonance and mass spectrometry correlation tables (1991) Vogel's Text Book of Practical Organic Chemistry, 5th Ed, pp. 1412-1441. , Furniss BS, Hannaford AJ, Smith PWG, Tatchell AR, eds., London, ELBS

PY - 2002

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AB - A systematic chemical investigation of Coronopus didymus was undertaken. A new flavone glycoside, viz., chrysoeriol-(6″-OAc)-4′-β-D-glucoside, along with free chrysoeriol and stigmastanol, were isolated and characterized on the basis of chemical and spectral studies. The ethanol and aqueous extracts of the whole plant were subjected to anti-inflammatory and wound healing activity studies. Both ethanol and aqueous extracts showed statistically significant wound healing activity, whereas only the aqueous extract showed significant anti-inflammatory activity.

U2 - 10.1076/phbi.40.7.490.14684

DO - 10.1076/phbi.40.7.490.14684

M3 - Article

VL - 40

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EP - 493

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 7

ER -