Abstract

The main purpose of this work was to study the chemical stability of optimized bioadhesive topical gel. For that Bioadhesive topical gel formulation was optimized on the basis of bioadhesive strength and invitro drug permeation study of prepared bioadhesive topical gel. To achieve the objectives of present study, BNTGs were prepared using natural bioadhesive polymer Aegel marmelos (plant Bale) and hydroxyethyl cellulose (HEC). Bioadhesive strength of BNTG3 was found to be 1.72±0.023 gm/cm2. BNTG3 permeates only 89.00%±0.59% over 24 h. The shelf life of BNTG3 was found to be 0.439 years and 0.302 years at 25±2°C and 40±2°C, respectively. Degradation half-life of BNTG3 was found to be 2.902 years and 1.996 years at 25±2°C and 40±2°C, respectively. Activation energy was found to be 4631.7003 cal/mol. All the data was found to be extremely significant by studying one way ANOVA at p<0.05 level. In last it was concluded that, BNTG3 will be more effective and stable if it is ored at or below 25±2°C. So, BNTG3 was successfully developed and standardized for improved topical therapeutics.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume3
Issue number1
Publication statusPublished - 01-02-2011

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Gels
Cellulose
Half-Life
Analysis of Variance
Polymers
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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title = "Chemical stability studies of bioadhesive topical gel",
abstract = "The main purpose of this work was to study the chemical stability of optimized bioadhesive topical gel. For that Bioadhesive topical gel formulation was optimized on the basis of bioadhesive strength and invitro drug permeation study of prepared bioadhesive topical gel. To achieve the objectives of present study, BNTGs were prepared using natural bioadhesive polymer Aegel marmelos (plant Bale) and hydroxyethyl cellulose (HEC). Bioadhesive strength of BNTG3 was found to be 1.72±0.023 gm/cm2. BNTG3 permeates only 89.00{\%}±0.59{\%} over 24 h. The shelf life of BNTG3 was found to be 0.439 years and 0.302 years at 25±2°C and 40±2°C, respectively. Degradation half-life of BNTG3 was found to be 2.902 years and 1.996 years at 25±2°C and 40±2°C, respectively. Activation energy was found to be 4631.7003 cal/mol. All the data was found to be extremely significant by studying one way ANOVA at p<0.05 level. In last it was concluded that, BNTG3 will be more effective and stable if it is ored at or below 25±2°C. So, BNTG3 was successfully developed and standardized for improved topical therapeutics.",
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Chemical stability studies of bioadhesive topical gel. / Kumar, Lalit; Verma, Ruchi.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 3, No. 1, 01.02.2011, p. 101-104.

Research output: Contribution to journalArticle

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