Chemoradiation related acute morbidity in carcinoma cervix and correlation with hematologic toxicity: A South Indian prospective study

Aswathy Kumaran, Shyamala Guruvare, Krishna Sharan, Lavanya Rai, Shripad Hebbar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage. Materials and Methods: A prospective study was carried out between August 2012 and July 2013 enrolling 79 women with cancer cervix receiving chemo-radiotherapy. Weekly assessment of acute morbidity was done using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 and the toxicities were graded. Results: Anemia [77 (97.5%)], vomiting [75 (94.8%)] and diarrhea [72 (91.1%)], leukopenia [11 (13.9%)], cystitis [28 (35.4%], dermatitis [19 (24.1%)] and fatigue [29 (36.71%)] were the acute toxicities noted. The toxicities were most severe in 3rd and 5th week. All women could complete radiotherapy except two due to causes unrelated to radiation morbidity; seven (8.86%) had to discontinue chemotherapy due to leukopenia and intractable diarrhea. Though there was no correlation between anemia and other toxicities, it was found that all with leukopenia had diarrhea. Conclusions: Chemoradiation for cancer cervix is on the whole well tolerated. Leukopenia and severe diarrhea were the acute toxicities that compelled discontinuation of chemotherapy in two women. Though anemia had no correlation with gastrointestinal toxicity, all of those with leukopenia had diarrhea.

Original languageEnglish
Pages (from-to)4483-4486
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number11
DOIs
Publication statusPublished - 01-01-2014

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Leukopenia
Cervix Uteri
Diarrhea
Prospective Studies
Morbidity
Carcinoma
Anemia
Uterine Cervical Neoplasms
Radiotherapy
Drug Therapy
Cystitis
National Cancer Institute (U.S.)
Dermatitis
Terminology
Vomiting
Fatigue
Radiation

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

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title = "Chemoradiation related acute morbidity in carcinoma cervix and correlation with hematologic toxicity: A South Indian prospective study",
abstract = "Purpose: To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage. Materials and Methods: A prospective study was carried out between August 2012 and July 2013 enrolling 79 women with cancer cervix receiving chemo-radiotherapy. Weekly assessment of acute morbidity was done using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 and the toxicities were graded. Results: Anemia [77 (97.5{\%})], vomiting [75 (94.8{\%})] and diarrhea [72 (91.1{\%})], leukopenia [11 (13.9{\%})], cystitis [28 (35.4{\%}], dermatitis [19 (24.1{\%})] and fatigue [29 (36.71{\%})] were the acute toxicities noted. The toxicities were most severe in 3rd and 5th week. All women could complete radiotherapy except two due to causes unrelated to radiation morbidity; seven (8.86{\%}) had to discontinue chemotherapy due to leukopenia and intractable diarrhea. Though there was no correlation between anemia and other toxicities, it was found that all with leukopenia had diarrhea. Conclusions: Chemoradiation for cancer cervix is on the whole well tolerated. Leukopenia and severe diarrhea were the acute toxicities that compelled discontinuation of chemotherapy in two women. Though anemia had no correlation with gastrointestinal toxicity, all of those with leukopenia had diarrhea.",
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Chemoradiation related acute morbidity in carcinoma cervix and correlation with hematologic toxicity : A South Indian prospective study. / Kumaran, Aswathy; Guruvare, Shyamala; Sharan, Krishna; Rai, Lavanya; Hebbar, Shripad.

In: Asian Pacific Journal of Cancer Prevention, Vol. 15, No. 11, 01.01.2014, p. 4483-4486.

Research output: Contribution to journalArticle

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