Childhood and adolescent meningiomas: A report of 38 cases and review of literature

G. Menon, S. Nair, J. Sudhir, B.R.M. Rao, A. Mathew, B. Bahuleyan

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Summary: Background: The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. Method: A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed. The variables analysed included age, sex, presentation, associated neurofibromatosis (NF), imaging characteristics, extent of resection and histopathology. Results: The study group included 20 males and 18 females with a mean age of 15.53 years. Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas. The common presenting symptoms were seizures (76.3%), raised intracranial tension (71%), and focal neurological deficits (39.4%). The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%). Two children (4.9%) had cystic meningiomas. Grade I excision was achieved only in twenty tumours (48.8%). On histopathology, thirty (73.2%) were grade I, nine (21.9%) were grade II and two (4.9%) were grade III meningiomas. Seven tumours recurred of which six were located at the skull base. During the mean follow up period of 4.74 years, the majority, 32 (84.2%) had a good outcome and five (13.2%) had a poor outcome. One child (2.6%) expired due to post-operative sepsis. Conclusion: Childhood meningiomas are uncommon but not rare lesions with a marginal male predominance. Absence of large series with long follow up precludes any definite conclusions on the clinical course and outcome. Uniform observations made in different series including ours, include a higher incidence of the skull base location and tumours with atypical histopathology. Favourable prognostic factors include younger age (
Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalActa Neurochirurgica
Volume151
Issue number3
DOIs
Publication statusPublished - 2009

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Meningioma
Skull Base
Neurofibromatoses
Neoplasms
Acoustic Neuroma
Optic Nerve
Sepsis
Seizures
Incidence

Cite this

Menon, G. ; Nair, S. ; Sudhir, J. ; Rao, B.R.M. ; Mathew, A. ; Bahuleyan, B. / Childhood and adolescent meningiomas: A report of 38 cases and review of literature. In: Acta Neurochirurgica. 2009 ; Vol. 151, No. 3. pp. 239-244.
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abstract = "Summary: Background: The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. Method: A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed. The variables analysed included age, sex, presentation, associated neurofibromatosis (NF), imaging characteristics, extent of resection and histopathology. Results: The study group included 20 males and 18 females with a mean age of 15.53 years. Eleven children (28.9{\%}) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas. The common presenting symptoms were seizures (76.3{\%}), raised intracranial tension (71{\%}), and focal neurological deficits (39.4{\%}). The location of the operated tumours were as follows: ten skull base (24.4{\%}), ten falx/parasagittal (24.4{\%}), eight spinal (19.5{\%}), five convexity (12.2{\%}), three posterior fossa (7.3{\%}), three intraventricular (7.3{\%}) and two optic nerve sheath (4.9{\%}). Two children (4.9{\%}) had cystic meningiomas. Grade I excision was achieved only in twenty tumours (48.8{\%}). On histopathology, thirty (73.2{\%}) were grade I, nine (21.9{\%}) were grade II and two (4.9{\%}) were grade III meningiomas. Seven tumours recurred of which six were located at the skull base. During the mean follow up period of 4.74 years, the majority, 32 (84.2{\%}) had a good outcome and five (13.2{\%}) had a poor outcome. One child (2.6{\%}) expired due to post-operative sepsis. Conclusion: Childhood meningiomas are uncommon but not rare lesions with a marginal male predominance. Absence of large series with long follow up precludes any definite conclusions on the clinical course and outcome. Uniform observations made in different series including ours, include a higher incidence of the skull base location and tumours with atypical histopathology. Favourable prognostic factors include younger age (",
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Childhood and adolescent meningiomas: A report of 38 cases and review of literature. / Menon, G.; Nair, S.; Sudhir, J.; Rao, B.R.M.; Mathew, A.; Bahuleyan, B.

In: Acta Neurochirurgica, Vol. 151, No. 3, 2009, p. 239-244.

Research output: Contribution to journalArticle

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T1 - Childhood and adolescent meningiomas: A report of 38 cases and review of literature

AU - Menon, G.

AU - Nair, S.

AU - Sudhir, J.

AU - Rao, B.R.M.

AU - Mathew, A.

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N2 - Summary: Background: The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. Method: A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed. The variables analysed included age, sex, presentation, associated neurofibromatosis (NF), imaging characteristics, extent of resection and histopathology. Results: The study group included 20 males and 18 females with a mean age of 15.53 years. Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas. The common presenting symptoms were seizures (76.3%), raised intracranial tension (71%), and focal neurological deficits (39.4%). The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%). Two children (4.9%) had cystic meningiomas. Grade I excision was achieved only in twenty tumours (48.8%). On histopathology, thirty (73.2%) were grade I, nine (21.9%) were grade II and two (4.9%) were grade III meningiomas. Seven tumours recurred of which six were located at the skull base. During the mean follow up period of 4.74 years, the majority, 32 (84.2%) had a good outcome and five (13.2%) had a poor outcome. One child (2.6%) expired due to post-operative sepsis. Conclusion: Childhood meningiomas are uncommon but not rare lesions with a marginal male predominance. Absence of large series with long follow up precludes any definite conclusions on the clinical course and outcome. Uniform observations made in different series including ours, include a higher incidence of the skull base location and tumours with atypical histopathology. Favourable prognostic factors include younger age (

AB - Summary: Background: The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. Method: A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed. The variables analysed included age, sex, presentation, associated neurofibromatosis (NF), imaging characteristics, extent of resection and histopathology. Results: The study group included 20 males and 18 females with a mean age of 15.53 years. Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas. The common presenting symptoms were seizures (76.3%), raised intracranial tension (71%), and focal neurological deficits (39.4%). The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%). Two children (4.9%) had cystic meningiomas. Grade I excision was achieved only in twenty tumours (48.8%). On histopathology, thirty (73.2%) were grade I, nine (21.9%) were grade II and two (4.9%) were grade III meningiomas. Seven tumours recurred of which six were located at the skull base. During the mean follow up period of 4.74 years, the majority, 32 (84.2%) had a good outcome and five (13.2%) had a poor outcome. One child (2.6%) expired due to post-operative sepsis. Conclusion: Childhood meningiomas are uncommon but not rare lesions with a marginal male predominance. Absence of large series with long follow up precludes any definite conclusions on the clinical course and outcome. Uniform observations made in different series including ours, include a higher incidence of the skull base location and tumours with atypical histopathology. Favourable prognostic factors include younger age (

U2 - 10.1007/s00701-009-0206-8

DO - 10.1007/s00701-009-0206-8

M3 - Article

VL - 151

SP - 239

EP - 244

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

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