Chondrolysis and the stiff hip in Perthes' disease: An immunological study

Benjamin Joseph, Ravi Kumar V Pydisetty

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The study was undertaken to determine whether immunologic mechanisms could account for hip stiffness and chondrolysis in Perthes' disease. Histologic and electron microscopic evidence of perivascular collections of plasma cells and lymphocytes in synovial tissue and the demonstration of elevated levels of circulating immunoglobulins in children with Perthes' disease suggest that immunologic processes are involved. Chondrolysis was observed only in children who were >10 years old, with a totally avascular epiphysis in the stage of fragmentation. Because the serum immunoglobulin levels were not dependent on age, extent of epiphyseal avascularity, and the degree of hip stiffness, monitoring of these levels is unlikely to be of help in predicting chondrolysis.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalJournal of Pediatric Orthopaedics
Volume16
Issue number1
DOIs
Publication statusPublished - 12-01-1996
Externally publishedYes

Fingerprint

Legg-Calve-Perthes Disease
Immunoglobulins
Hip
Epiphyses
Plasma Cells
Lymphocytes
Electrons
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Joseph, Benjamin ; Pydisetty, Ravi Kumar V. / Chondrolysis and the stiff hip in Perthes' disease : An immunological study. In: Journal of Pediatric Orthopaedics. 1996 ; Vol. 16, No. 1. pp. 15-19.
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Chondrolysis and the stiff hip in Perthes' disease : An immunological study. / Joseph, Benjamin; Pydisetty, Ravi Kumar V.

In: Journal of Pediatric Orthopaedics, Vol. 16, No. 1, 12.01.1996, p. 15-19.

Research output: Contribution to journalArticle

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