TY - JOUR
T1 - Chronic myeloid leukemia with hyperdiploidy
T2 - A case report with review of literature
AU - Belurkar, Sushma
AU - Manohar, Chethan
AU - Kurien, Annamma
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Chronic myeloid leukemia (CML) is a common marrow stem cell neoplasm characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Studies have shown that CML can be associated with various other cytogenetic abnormalities. 5-10% of these cases can show complex translocations involving other chromosomes in addition to Ph chromosome. Here, we report a Ph-positive CML patient with a hyperdiploid karyotype who presented clinically in chronic phase but progressed to blast crisis in spite of treatment with Imatinib. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML.
AB - Chronic myeloid leukemia (CML) is a common marrow stem cell neoplasm characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Studies have shown that CML can be associated with various other cytogenetic abnormalities. 5-10% of these cases can show complex translocations involving other chromosomes in addition to Ph chromosome. Here, we report a Ph-positive CML patient with a hyperdiploid karyotype who presented clinically in chronic phase but progressed to blast crisis in spite of treatment with Imatinib. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML.
UR - http://www.scopus.com/inward/record.url?scp=84893846389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893846389&partnerID=8YFLogxK
U2 - 10.4103/0019-5359.125881
DO - 10.4103/0019-5359.125881
M3 - Article
C2 - 24469564
AN - SCOPUS:84893846389
SN - 0019-5359
VL - 67
SP - 188
EP - 192
JO - Indian Journal of Medical Sciences
JF - Indian Journal of Medical Sciences
IS - 7-8
ER -