Chronic myeloid leukemia with hyperdiploidy: A case report with review of literature

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Abstract

Chronic myeloid leukemia (CML) is a common marrow stem cell neoplasm characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Studies have shown that CML can be associated with various other cytogenetic abnormalities. 5-10% of these cases can show complex translocations involving other chromosomes in addition to Ph chromosome. Here, we report a Ph-positive CML patient with a hyperdiploid karyotype who presented clinically in chronic phase but progressed to blast crisis in spite of treatment with Imatinib. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalIndian Journal of Medical Sciences
Volume67
Issue number7-8
DOIs
Publication statusPublished - 01-07-2013

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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