Clear cell primary seminal vesicle carcinoma in a young male-a rare case report

Primary malignancies of Seminal Vesicle (SV) are rare. When involved, it is most commonly due to secondaries or by contiguous spread from adjacent organs. Primary tumours that can arise in SV can be epithelial and mesenchymal. Adenocarcinoma is most common epithelial tumour, and the Clear Cell variant of Adenocarcinoma (CCA) so far has not been reported in literature. Primary SV malignancies like adenocarcinoma pose a diagnostic dilemma as it becomes difficult to differentiate it from secondaries or as involvement from other adjacent organs even with imaging, histopathology and Immunohistochemistry (IHC). Here we present a case of 34-year-old male who presented with occasional total painless haematuria for four years and was evaluated by Contrast Enhanced Computed Tomography (CECT) which revealed pelvic mass. After evaluation by biopsy, histopathology and IHC he was diagnosed as primary clear cell adenocarcinoma. Despite all investigations this malignancy is difficult to differentiate from mullerian duct cyst carcinoma.