Clinical and biochemical profile of steroid-induced diabetes

N. Karthik Rao, Navin Patil, Sudha Vidyasagar, N. R. Rau, Avinash Manjunath Holla, A. Avinash

Research output: Contribution to journalArticle

Abstract

Objective: To study the clinical and biochemical profile of patients who develop steroid-induced diabetes (SID) and its predisposing factors. Methods: Non-diabetic patients aged ≥18 years started on steroids were considered eligible for the study. In every case after detailed examination, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin, fasting insulin were measured prior to starting steroids and was repeated in 1st week (day 3/4) after starting steroid according to standard guidelines. FPG and PPG were repeated periodically during follow-up of the patients. The utility of Indian diabetic risk score (IDRS) score in predicting the risk for SID was also assessed. Result: Steroid-induced diabetes was found to be more in females than in males. IDRS is not useful in predicting the risk factors of SID. 97% of patients had an elevation of post-prandial sugars with or without fasting hyperglycemia, but only 3% of patients had isolated elevation of fasting blood sugar. 84% of patients developed SID during the 1st week of therapy. 33% of the cases SID persisted even after 1 month of stopping steroids and on a minimal dosage of steroids. Conclusion: Unlike type 2 diabetes, there were no significant risk factors such as age, family history of diabetes to develop SID and IDRS may not be a sensitive tool for predicting risk factors of SID. Monitoring of post-prandial sugars as compared to fasting sugars is essential for the screening of SID. Cumulative dose of steroid may not be important to precipitate steroid diabetes.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume9
Issue number2
Publication statusPublished - 01-03-2016

Fingerprint

Steroids
Fasting
Meals
Glucose
Glycosylated Hemoglobin A
Hyperglycemia
Causality
Type 2 Diabetes Mellitus
Blood Glucose
Guidelines
Insulin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Karthik Rao, N. ; Patil, Navin ; Vidyasagar, Sudha ; Rau, N. R. ; Holla, Avinash Manjunath ; Avinash, A. / Clinical and biochemical profile of steroid-induced diabetes. In: Asian Journal of Pharmaceutical and Clinical Research. 2016 ; Vol. 9, No. 2. pp. 262-266.
@article{9967fc56e69a4fc1aa270eac707e03b0,
title = "Clinical and biochemical profile of steroid-induced diabetes",
abstract = "Objective: To study the clinical and biochemical profile of patients who develop steroid-induced diabetes (SID) and its predisposing factors. Methods: Non-diabetic patients aged ≥18 years started on steroids were considered eligible for the study. In every case after detailed examination, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin, fasting insulin were measured prior to starting steroids and was repeated in 1st week (day 3/4) after starting steroid according to standard guidelines. FPG and PPG were repeated periodically during follow-up of the patients. The utility of Indian diabetic risk score (IDRS) score in predicting the risk for SID was also assessed. Result: Steroid-induced diabetes was found to be more in females than in males. IDRS is not useful in predicting the risk factors of SID. 97{\%} of patients had an elevation of post-prandial sugars with or without fasting hyperglycemia, but only 3{\%} of patients had isolated elevation of fasting blood sugar. 84{\%} of patients developed SID during the 1st week of therapy. 33{\%} of the cases SID persisted even after 1 month of stopping steroids and on a minimal dosage of steroids. Conclusion: Unlike type 2 diabetes, there were no significant risk factors such as age, family history of diabetes to develop SID and IDRS may not be a sensitive tool for predicting risk factors of SID. Monitoring of post-prandial sugars as compared to fasting sugars is essential for the screening of SID. Cumulative dose of steroid may not be important to precipitate steroid diabetes.",
author = "{Karthik Rao}, N. and Navin Patil and Sudha Vidyasagar and Rau, {N. R.} and Holla, {Avinash Manjunath} and A. Avinash",
year = "2016",
month = "3",
day = "1",
language = "English",
volume = "9",
pages = "262--266",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "2",

}

Clinical and biochemical profile of steroid-induced diabetes. / Karthik Rao, N.; Patil, Navin; Vidyasagar, Sudha; Rau, N. R.; Holla, Avinash Manjunath; Avinash, A.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, No. 2, 01.03.2016, p. 262-266.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and biochemical profile of steroid-induced diabetes

AU - Karthik Rao, N.

AU - Patil, Navin

AU - Vidyasagar, Sudha

AU - Rau, N. R.

AU - Holla, Avinash Manjunath

AU - Avinash, A.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: To study the clinical and biochemical profile of patients who develop steroid-induced diabetes (SID) and its predisposing factors. Methods: Non-diabetic patients aged ≥18 years started on steroids were considered eligible for the study. In every case after detailed examination, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin, fasting insulin were measured prior to starting steroids and was repeated in 1st week (day 3/4) after starting steroid according to standard guidelines. FPG and PPG were repeated periodically during follow-up of the patients. The utility of Indian diabetic risk score (IDRS) score in predicting the risk for SID was also assessed. Result: Steroid-induced diabetes was found to be more in females than in males. IDRS is not useful in predicting the risk factors of SID. 97% of patients had an elevation of post-prandial sugars with or without fasting hyperglycemia, but only 3% of patients had isolated elevation of fasting blood sugar. 84% of patients developed SID during the 1st week of therapy. 33% of the cases SID persisted even after 1 month of stopping steroids and on a minimal dosage of steroids. Conclusion: Unlike type 2 diabetes, there were no significant risk factors such as age, family history of diabetes to develop SID and IDRS may not be a sensitive tool for predicting risk factors of SID. Monitoring of post-prandial sugars as compared to fasting sugars is essential for the screening of SID. Cumulative dose of steroid may not be important to precipitate steroid diabetes.

AB - Objective: To study the clinical and biochemical profile of patients who develop steroid-induced diabetes (SID) and its predisposing factors. Methods: Non-diabetic patients aged ≥18 years started on steroids were considered eligible for the study. In every case after detailed examination, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin, fasting insulin were measured prior to starting steroids and was repeated in 1st week (day 3/4) after starting steroid according to standard guidelines. FPG and PPG were repeated periodically during follow-up of the patients. The utility of Indian diabetic risk score (IDRS) score in predicting the risk for SID was also assessed. Result: Steroid-induced diabetes was found to be more in females than in males. IDRS is not useful in predicting the risk factors of SID. 97% of patients had an elevation of post-prandial sugars with or without fasting hyperglycemia, but only 3% of patients had isolated elevation of fasting blood sugar. 84% of patients developed SID during the 1st week of therapy. 33% of the cases SID persisted even after 1 month of stopping steroids and on a minimal dosage of steroids. Conclusion: Unlike type 2 diabetes, there were no significant risk factors such as age, family history of diabetes to develop SID and IDRS may not be a sensitive tool for predicting risk factors of SID. Monitoring of post-prandial sugars as compared to fasting sugars is essential for the screening of SID. Cumulative dose of steroid may not be important to precipitate steroid diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84960125962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960125962&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84960125962

VL - 9

SP - 262

EP - 266

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 2

ER -