Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study

M. Murugesan, K. Shringarpure, D. S.A. Karthickeyan, C. K. Nair, S. K. Nayanar, V. Venugopal, K. Selvaraj, P. Rathi, K. G. Metha, V. Deenathayalan, G. K. Chellaiya

Research output: Contribution to journalArticle

Abstract

Background: PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation. However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40% of patients during the first collection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34 yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia). Methods: Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency, clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield during the first collection was studied. Factors such as collection efficiency, percentage platelet loss and percentage hemoglobin loss were considered to compare the two apheresis system. Results: Two-third (72%) patients of the study population had adequate CD34 stem cells yield during the first collection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC count and CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiency than MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedure duration (277 vs 360 min), whereas the median Hb loss (3.0% and 2.3%) and mean platelet loss (49% and 34%) were higher with MCS. Conclusion: This study infers that the collection efficiency of both the equipments in collecting CD34 stem cells was similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patients with risk of anemia and thrombocytopenia.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalTransfusion and Apheresis Science
Volume58
Issue number4
DOIs
Publication statusPublished - 01-08-2019
Externally publishedYes

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Autografts
Blood Component Removal
Cohort Studies
Retrospective Studies
Equipment and Supplies
Neoplasms
Stem Cells
Blood Platelets
Hematopoietic Stem Cell Transplantation
Thrombocytopenia
Anemia
Hemoglobins
Peripheral Blood Stem Cells
Population

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Murugesan, M. ; Shringarpure, K. ; Karthickeyan, D. S.A. ; Nair, C. K. ; Nayanar, S. K. ; Venugopal, V. ; Selvaraj, K. ; Rathi, P. ; Metha, K. G. ; Deenathayalan, V. ; Chellaiya, G. K. / Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study. In: Transfusion and Apheresis Science. 2019 ; Vol. 58, No. 4. pp. 457-463.
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title = "Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study",
abstract = "Background: PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation. However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40{\%} of patients during the first collection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34 yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia). Methods: Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency, clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield during the first collection was studied. Factors such as collection efficiency, percentage platelet loss and percentage hemoglobin loss were considered to compare the two apheresis system. Results: Two-third (72{\%}) patients of the study population had adequate CD34 stem cells yield during the first collection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC count and CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiency than MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedure duration (277 vs 360 min), whereas the median Hb loss (3.0{\%} and 2.3{\%}) and mean platelet loss (49{\%} and 34{\%}) were higher with MCS. Conclusion: This study infers that the collection efficiency of both the equipments in collecting CD34 stem cells was similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patients with risk of anemia and thrombocytopenia.",
author = "M. Murugesan and K. Shringarpure and Karthickeyan, {D. S.A.} and Nair, {C. K.} and Nayanar, {S. K.} and V. Venugopal and K. Selvaraj and P. Rathi and Metha, {K. G.} and V. Deenathayalan and Chellaiya, {G. K.}",
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Murugesan, M, Shringarpure, K, Karthickeyan, DSA, Nair, CK, Nayanar, SK, Venugopal, V, Selvaraj, K, Rathi, P, Metha, KG, Deenathayalan, V & Chellaiya, GK 2019, 'Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study', Transfusion and Apheresis Science, vol. 58, no. 4, pp. 457-463. https://doi.org/10.1016/j.transci.2019.05.007

Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study. / Murugesan, M.; Shringarpure, K.; Karthickeyan, D. S.A.; Nair, C. K.; Nayanar, S. K.; Venugopal, V.; Selvaraj, K.; Rathi, P.; Metha, K. G.; Deenathayalan, V.; Chellaiya, G. K.

In: Transfusion and Apheresis Science, Vol. 58, No. 4, 01.08.2019, p. 457-463.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study

AU - Murugesan, M.

AU - Shringarpure, K.

AU - Karthickeyan, D. S.A.

AU - Nair, C. K.

AU - Nayanar, S. K.

AU - Venugopal, V.

AU - Selvaraj, K.

AU - Rathi, P.

AU - Metha, K. G.

AU - Deenathayalan, V.

AU - Chellaiya, G. K.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation. However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40% of patients during the first collection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34 yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia). Methods: Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency, clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield during the first collection was studied. Factors such as collection efficiency, percentage platelet loss and percentage hemoglobin loss were considered to compare the two apheresis system. Results: Two-third (72%) patients of the study population had adequate CD34 stem cells yield during the first collection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC count and CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiency than MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedure duration (277 vs 360 min), whereas the median Hb loss (3.0% and 2.3%) and mean platelet loss (49% and 34%) were higher with MCS. Conclusion: This study infers that the collection efficiency of both the equipments in collecting CD34 stem cells was similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patients with risk of anemia and thrombocytopenia.

AB - Background: PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation. However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40% of patients during the first collection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34 yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia). Methods: Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency, clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield during the first collection was studied. Factors such as collection efficiency, percentage platelet loss and percentage hemoglobin loss were considered to compare the two apheresis system. Results: Two-third (72%) patients of the study population had adequate CD34 stem cells yield during the first collection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC count and CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiency than MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedure duration (277 vs 360 min), whereas the median Hb loss (3.0% and 2.3%) and mean platelet loss (49% and 34%) were higher with MCS. Conclusion: This study infers that the collection efficiency of both the equipments in collecting CD34 stem cells was similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patients with risk of anemia and thrombocytopenia.

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JO - Transfusion and Apheresis Science

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